{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:25:06Z","timestamp":1777551906947,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    The aim of this study was to identify biomarkers of dermatomyositis (DM). The analysis was conducted by retrieving DM-related cDNA microarray data sets from public databases. Gene ontology, Kyoto encyclopedia of genes and genomes, and protein\u2013protein interaction analyses were performed, together with quantitative PCR-based detection of biomarkers in muscle tissue after stimulation with serum from patients with DM or healthy controls. Our analysis of five microarray data sets identified 20 common differentially expressed genes that are closely associated with DM. PCR analysis showed that mRNAs of\n                    <jats:italic toggle=\"yes\">IFITM2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">LY6E<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">DDX58<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">IFI6<\/jats:italic>\n                    were expressed at significantly higher levels in the muscle tissue of patients with DM than in normal muscle tissues. These mRNAs were also upregulated in human skeletal muscle cells stimulated with the serum from patients with DM. The results of integrated analyses of the DM microarray data and the mRNA levels of genes showed significant differences between the muscle tissues of DM patients and controls, which could indicate key pathogenic genes and novel therapeutic targets for DM.\n                  <\/jats:p>","DOI":"10.1089\/dna.2018.4256","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T16:22:33Z","timestamp":1541089353000},"page":"982-992","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Discovery of Key Genes in Dermatomyositis Based on the Gene Expression Omnibus Database"],"prefix":"10.1177","volume":"37","author":[{"given":"Shuoshan","family":"Xie","sequence":"first","affiliation":[{"name":"Rheumatology Department, Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huali","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Zuo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.06.012"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.05.021"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-9-43"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402225"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24669"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160293"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12449"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2799-4"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.07.021"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1632-x"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000291619.17160.b8"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4355"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20464"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202794"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03540-6"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr988"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-016-6322-2"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw525"},{"key":"e_1_3_4_23_1","first-page":"7258","article-title":"Effects of serum on cytochrome C oxidase activity and mitochondrial energy load in mitochondrial membrane of skeletal muscle cells during sub healthy fatigue","volume":"12","author":"Li B.","year":"2008","unstructured":"Li B., , Zhao X., , Luo R., , Sun X., , Li J., , and Chen J. (2008). Effects of serum on cytochrome C oxidase activity and mitochondrial energy load in mitochondrial membrane of skeletal muscle cells during sub healthy fatigue. Tissue Eng Res Clin Rehabil China, 12, 7258\u20137262.","journal-title":"Tissue Eng Res Clin Rehabil China"},{"key":"e_1_3_4_24_1","first-page":"2095","article-title":"Effects of sub healthy fatigue serum on protein expression in skeletal muscle cells","volume":"13","author":"Li B.","year":"2009","unstructured":"Li B., , Zhao X., , Luo R., , Sun X., , Chen J., , and Li J. (2009). Effects of sub healthy fatigue serum on protein expression in skeletal muscle cells. Tissue Eng Res Clin Rehabil China, 13, 2095\u20132100.","journal-title":"Tissue Eng Res Clin Rehabil China"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19050"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094128"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9070082"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05119.x"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv192"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.03.012"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.092"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091418"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24555"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.6706"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.5808\/GI.2013.11.1.15"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.5130"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1977"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9695"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21805"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38400"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0112"},{"key":"e_1_3_4_43_1","first-page":"363","article-title":"Risk of cancer in patients with dermatomyositis or polymyositis","volume":"326","author":"Sigurgeirsson B.","year":"1992","unstructured":"Sigurgeirsson B., , Lindel\u00f6f B., , Edhag O., , and Allander E. (1992). Risk of cancer in patients with dermatomyositis or polymyositis. A population-based study. N Engl J Med, 326, 363\u2013367.","journal-title":"A population-based study. N Engl J Med"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4346"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12909"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01066.x"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308089694"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4250"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.06.005"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22928"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029161"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3006"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4447"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401249"},{"key":"e_1_3_4_55_1","doi-asserted-by":"crossref","first-page":"e0169553","DOI":"10.1371\/journal.pone.0169553","article-title":"Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes related to the type I interferon pathway","author":"Yeung K.S.","year":"2017","unstructured":"Yeung K.S., , Chung B.H.-Y., , Choufani S., , Mok M.Y., , Wong W.L., , Mak C.C.Y., et al.. (2017). Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes related to the type I interferon pathway. PLoS One 12, e0169553.","journal-title":"PLoS One 12,"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.755819"},{"key":"e_1_3_4_57_1","first-page":"1855","article-title":"The overall and temporal association of cancer with polymyositis and dermatomyositis","volume":"21","author":"Zantos D.","year":"1994","unstructured":"Zantos D., , Zhang Y., , and Felson D. (1994). The overall and temporal association of cancer with polymyositis and dermatomyositis. J Rheumatol, 21, 1855\u20131859.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1050-x"}],"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dna.2018.4256","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2018.4256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2018.4256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:56:16Z","timestamp":1777398976000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dna.2018.4256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1089\/dna.2018.4256"],"URL":"https:\/\/doi.org\/10.1089\/dna.2018.4256","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}