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Our results showed that the miR-30a-5p and mucin type O-glycan biosynthesis are closely related to ovarian cancer, and that miR-30a-5p was downregulated in ovarian cancer cells. miR-30a-5p overexpression reduced cell viability and inhibited migration and invasion in HO-8910 and HO-8910PM cells. S phase kinase-associated protein 2 (SKP2), B cell lymphoma 9 (BCL9), and NOTHC1 are direct target genes of miR-30a-5p. MTDH, SKP2, BCL9, and NOTCH1 genes were overexpressed in ovarian cancer cells, and they are direct target genes of miR-30a-5p. miR-30a-5p overexpression inhibited epithelial\u2013mesenchymal transition (EMT) process, while upregulation of SKP2, BCL9, and NOTCH1 gene expression levels reduced the inhibition of EMT process by miR-30a-5p. miR-30a-5p was lowly expressed in ovarian cancer, and such a phenomenon is related to ovarian cancer metastasis. miR-30a-5p might inhibit the migration and invasion of ovarian cancer cells by downregulating the expression of SKP2, BCL9, and NOTCH1 genes.<\/jats:p>","DOI":"10.1089\/dna.2018.4396","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T11:45:41Z","timestamp":1551872741000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Mechanism of Low Expression of\n                    <i>miR-30a-5p<\/i>\n                    on Epithelial\u2013Mesenchymal Transition and Metastasis in Ovarian Cancer"],"prefix":"10.1177","volume":"38","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital &amp; Institute, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital &amp; Institute, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxin","family":"Yu","sequence":"additional","affiliation":[{"name":"The Second Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital &amp; Institute, Shenyang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30024-1"},{"key":"e_1_3_2_3_1","first-page":"179","article-title":"The O-glycan pathway is associated with in vitro sensitivity to gemcitabine and overall survival from ovarian cancer","volume":"41","author":"Bou Zgheib N.","year":"2012","unstructured":"Bou Zgheib N., , Xiong Y., , Marchion D.C., , Bicaku E., , Chon H.S., , Stickles X.B., et al. 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