{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:30:33Z","timestamp":1790749833944,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Abnormal expression of O-Linked \u03b2-N-acetylglucosamine (O-GlcNAc) and \u03b2-catenin is a general feature of cancer and contributes to transformed phenotypes. In this study, we identified the interaction between O-GlcNAc and \u03b2-catenin, and explored their effects on the progression of liver cancer. Our results demonstrated that upregulation of O-GlcNAc was induced by high glucose, whereas the application of PuGNAc and GlcNAc increased \u03b2-catenin protein expression levels, as well as the protein's stability and nuclear accumulation in the liver cancer cell lines HEP-G2 and HuH-7. In addition, overexpression of \u03b2-catenin could increase O-GlcNAc expression levels through upregulation of uridine 5\u2032-diphosphate (UDP)-N-acetylglucosamine pyrophosphorylase 1 (UAP1) protein expression, protein stability, and inhibition of its ubiquitination. Moreover, the O-GlcNAcylation of \u03b2-catenin promoted the proliferation, colony formation, and repressed the induction of apoptosis in HEP-G2 and HuH-7 cells. Knockdown of \u03b2-catenin reduced cell proliferation, colony formation, and tumorigenesis, and promoted cell apoptosis through the downregulation of UAP1 expression. In conclusion, this study revealed that the reciprocal regulation between O-GlcNAcylation and \u03b2-catenin facilitated the proliferation of liver cancer.<\/jats:p>","DOI":"10.1089\/dna.2018.4447","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T10:35:45Z","timestamp":1550140545000},"page":"286-296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Reciprocal Regulation Between O-GlcNAcylation and \u03b2-Catenin Facilitates Cell Viability and Inhibits Apoptosis in Liver Cancer"],"prefix":"10.1177","volume":"38","author":[{"given":"Sicheng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Hepatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. 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