{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:12:09Z","timestamp":1778613129517,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    O\n                    <jats:sup>6<\/jats:sup>\n                    -Methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs the DNA damage caused by the tobacco habit, and low activity of this enzyme has been associated with a risk of lung cancer (LC). Our objective was to determine the association of the promoter methylation and the rs12917 polymorphism of\n                    <jats:italic toggle=\"yes\">MGMT<\/jats:italic>\n                    with formation of DNA bulky adducts and the risk of LC in the Mexican Mestizo population. In this study are included 431 subjects. High-resolution melting analysis was used to determine the polymorphism\n                    <jats:italic toggle=\"yes\">MGMT<\/jats:italic>\n                    rs12917 and methylation levels. DNA bulky adducts were determined by\n                    <jats:sup>32<\/jats:sup>\n                    P-postlabeling. Our results showed that\n                    <jats:italic toggle=\"yes\">MGMT<\/jats:italic>\n                    rs12917 and higher levels of methylation in the\n                    <jats:italic toggle=\"yes\">MGMT<\/jats:italic>\n                    promoter are associated with the risk of LC. The levels of adducts are related with the phe\/phe genotype and, only in the cases group, with the hypermethylation (&gt;50%) of\n                    <jats:italic toggle=\"yes\">MGMT<\/jats:italic>\n                    ; however, this last association was not statistically significant.\n                  <\/jats:p>","DOI":"10.1089\/dna.2018.4526","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T15:28:17Z","timestamp":1550676497000},"page":"307-313","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of the Promoter Methylation and the rs12917 Polymorphism of\n                    <i>MGMT<\/i>\n                    with Formation of DNA Bulky Adducts and the Risk of Lung Cancer in Mexican Mestizo Population"],"prefix":"10.1177","volume":"38","author":[{"given":"Ollin Celeste","family":"Mart\u00ednez-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Aut\u00f3noma del Estado de Morelos, Cuernavaca, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"P\u00e9rez-Morales","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Facultad de Ciencias Qu\u00edmicas, Universidad Ju\u00e1rez del Estado de Durango, Durango, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clementina","family":"Castro-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eugenia","family":"Gonsebatt","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonora","family":"Casas-\u00c1vila","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Instituto Nacional de Rehabilitaci\u00f3n, Ciudad de M\u00e9xico, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Vald\u00e9s-Flores","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Instituto Nacional de Rehabilitaci\u00f3n, Ciudad de M\u00e9xico, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Petrosyan","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria Ponce","family":"de Le\u00f3n-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica, Instituto Nacional de Rehabilitaci\u00f3n, Ciudad de M\u00e9xico, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julieta","family":"Rubio","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9078"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201312078"},{"key":"e_1_3_5_4_1","first-page":"793","article-title":"Advances in brief inactivation of the DNA repair gene O6-Methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia 1","author":"Esteller M.","year":"1999","unstructured":"Esteller M., , Hamilton S.R., , Burger P.C., , Baylin S.B., , and Herman J.G. 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