{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:27:26Z","timestamp":1777552046483,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n                    Diabetes mellitus is a complicated metabolic disease characterized by hyperglycemia. Diabetic nephropathy (DN) is a progressive kidney disease, which results in mortality in diabetic patients. The present study was designed to investigate the effect of applying spironolactone (S), captopril (C), and their combination (S+C) on some renal performance indices and microRNAs' (miRNAs) expression. A total of 35 two-month-old male Wistar rats were provided for the study. Intraperitoneal injection of freshly dissolved streptozotocin (60\u2009mg\/kg) in cold citrate buffer was used to induce diabetes. Blood samples were examined through calorimetry to assess serum concentrations of glucose, blood urea nitrogen (BUN), and creatinine. To measure the microalbuminuria and transforming growth factor-\u03b2 (TGF-\u03b2) levels and to evaluate the miRNAs expression levels of the kidney tissue, the ELISA method and the real-time PCR were used. The obtained results serve as\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    evidence for the positive relationship between miR-192 and TGF-\u03b2 levels in the DN rats. A significant increase and decrease were found for miR-29a\/b\/c and the miR-192 expression of DN after treatment with S, C, and S+C. TGF-\u03b2 levels and microalbuminuria of diabetic rats also increased. The results obtained from this research study suggest that S, C, and S\u2009+\u2009C can improve DN by targeting miR-192 and miR-29 family and changing their expression. These findings suggest that miR-192 and miRs-29a\/b\/c can be potential targets for DN remediation.\n                  <\/jats:p>","DOI":"10.1089\/dna.2019.4732","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T10:44:25Z","timestamp":1566384265000},"page":"1134-1142","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a\/b\/c"],"prefix":"10.1177","volume":"38","author":[{"given":"Zahra","family":"Ebadi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariman","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran."},{"name":"Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toktam","family":"Kazemi Fard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tourandokht","family":"Balochnejadmojarrad","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Chamani","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Research Center, Department of Biochemistry, Birjand University of Medical Sciences, Birjand, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Fadaei","sequence":"additional","affiliation":[{"name":"Sleep Disorder Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soudabeh","family":"Fallah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2054358117705371"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00131.x"},{"key":"e_1_3_3_4_1","doi-asserted-by":"crossref","unstructured":"Chin D. 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