{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:27:58Z","timestamp":1777552078482,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Transmembrane protein 39A (\n                    <jats:italic toggle=\"yes\">TMEM39A<\/jats:italic>\n                    ) gene polymorphisms have been related to various autoimmune diseases, but the relationship between\n                    <jats:italic toggle=\"yes\">TMEM39A<\/jats:italic>\n                    polymorphisms and autoimmune thyroid disease (AITD) remains unknown. This study was aimed at investigating whether the polymorphisms of the\n                    <jats:italic toggle=\"yes\">TMEM39A<\/jats:italic>\n                    were associated with AITD in the Chinese Han population. A case\u2013control study was performed in a total of 906 AITD patients and 744 healthy controls. Four single nucleotide polymorphisms, including rs1132200, rs12492609, rs2282175, and rs7629750, in\n                    <jats:italic toggle=\"yes\">TMEM39A<\/jats:italic>\n                    were examined by polymerase chain reaction-ligase detection reaction. We found that the allele T of rs12492609 in\n                    <jats:italic toggle=\"yes\">TMEM39A<\/jats:italic>\n                    was associated with AITD and Hashimoto's thyroiditis (HT) (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.023;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.028 respectively). Compared with controls, the frequency of haplotype CCA in AITD patients was higher than that in controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.036), but the frequency of haplotype CTA in AITD and HT patients was lower than that in controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.046;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.047 respectively). In addition, the frequency of allele A at rs7629750 in AITD patients with onset age \u226418 years old was higher than that in AITD patients with onset age \u226519 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.046). Further, there was an obvious difference in the genotype distributions of rs12492609 and rs7629750 between HT patients with hypothyroidism and those without hypothyroidism (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.034 and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.023, respectively). Our study first reveals that the polymorphisms of the\n                    <jats:italic toggle=\"yes\">TMEM39A<\/jats:italic>\n                    gene are associated with the susceptibility to AITD, especially for early-onset AITD and HT with hypothyroidism.\n                  <\/jats:p>","DOI":"10.1089\/dna.2019.4872","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T10:54:29Z","timestamp":1569408869000},"page":"1249-1256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Genetic Variants in\n                    <i>TMEM39A<\/i>\n                    Gene Are Associated with Autoimmune Thyroid Diseases"],"prefix":"10.1177","volume":"38","author":[{"given":"Qiuming","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-an","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"e_1_3_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.016"},{"key":"e_1_3_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072503322021106"},{"key":"e_1_3_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-017-0405-8"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125194.27381.D4"},{"key":"e_1_3_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.192384"},{"key":"e_1_3_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp542"},{"key":"e_1_3_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.02.023"},{"key":"e_1_3_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487870"},{"key":"e_1_3_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1402"},{"key":"e_1_3_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8312-8"},{"key":"e_1_3_8_12_1","first-page":"962","article-title":"Genetic anticipation in rheumatoid arthritis in Europe","volume":"28","author":"Radstake T.R.","year":"2001","unstructured":"Radstake T.R., , Barrera P., , Albers M.J., , Swinkels H.L., , van de Putte L.B., , van Riel P.L., et al. (2001). Genetic anticipation in rheumatoid arthritis in Europe. European Consortium on Rheumatoid Arthritis Families. J Rheumatol, 28, 962\u2013967.","journal-title":"European Consortium on Rheumatoid Arthritis Families. J Rheumatol"},{"key":"e_1_3_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20037"},{"key":"e_1_3_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0602-9"},{"key":"e_1_3_8_15_1","first-page":"3428236","article-title":"Variants of interleukin-22 gene confer predisposition to autoimmune thyroid disease","author":"Song R.H.","year":"2017","unstructured":"Song R.H., , Li Q., , Wang W., , Yao Q.M., , Shao X.Q., , and Zhang J.A. (2017). Variants of interleukin-22 gene confer predisposition to autoimmune thyroid disease. Int J Endocrinol 2017, 3428236.","journal-title":"Int J Endocrinol 2017,"},{"key":"e_1_3_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.10.013"},{"key":"e_1_3_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081369"},{"key":"e_1_3_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0030"},{"key":"e_1_3_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.02.007"},{"key":"e_1_3_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511432741"},{"key":"e_1_3_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-017-0921-1"},{"key":"e_1_3_8_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-15-0144"},{"key":"e_1_3_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9510-1"},{"key":"e_1_3_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12522"}],"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dna.2019.4872","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2019.4872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2019.4872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:56:52Z","timestamp":1777399012000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dna.2019.4872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1089\/dna.2019.4872"],"URL":"https:\/\/doi.org\/10.1089\/dna.2019.4872","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,30]]}}}