{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:14:30Z","timestamp":1782256470727,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    Chemoresistance is one of the major obstacles for cancer therapy. Abnormal expression of long noncoding RNAs (lncRNAs) was broadly implicated in chemoresistance of multiple cancers. This study was aimed to investigate the function of urothelial cancer associated 1 (\n                    <jats:italic toggle=\"yes\">UCA1<\/jats:italic>\n                    ) in multidrug resistance of retinoblastoma and its potential molecular mechanism. In this study, we observed that\n                    <jats:italic toggle=\"yes\">UCA1<\/jats:italic>\n                    was significantly upregulated in chemoresistant retinoblastoma tissues and multidrug resistant retinoblastoma cell lines and predicted an unfavorable overall survival. Functionally, knockdown of\n                    <jats:italic toggle=\"yes\">UCA1<\/jats:italic>\n                    remarkably inhibited proliferation and sensitized retinoblastoma cells to multiple chemotherapy drugs, including vincristine (VCR), carboplatin (CBP), cisplatin (DDP), VP-16 (etoposide), and 5-fluorouracil (5-Fu). Mechanistic studies demonstrated that\n                    <jats:italic toggle=\"yes\">UCA1<\/jats:italic>\n                    functioned as a miRNA sponge to increase stathmin 1 (\n                    <jats:italic toggle=\"yes\">STMN1<\/jats:italic>\n                    ) expression through sponging miR-513a-5p. In addition, silence of miR-513a-5p or\n                    <jats:italic toggle=\"yes\">STMN1<\/jats:italic>\n                    overexpression could partly reverse\n                    <jats:italic toggle=\"yes\">UCA1<\/jats:italic>\n                    knockdown-induced inhibitory effects on proliferation and multidrug resistance of retinoblastoma cells. Overall, this study is the first to demonstrate that\n                    <jats:italic toggle=\"yes\">UCA1<\/jats:italic>\n                    plays a critical role in retinoblastoma chemoresistance, and\n                    <jats:italic toggle=\"yes\">UCA1<\/jats:italic>\n                    may serve as a potential diagnostic biomarker and therapeutic target of retinoblastoma.\n                  <\/jats:p>","DOI":"10.1089\/dna.2019.5063","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T10:50:47Z","timestamp":1573210247000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["lncRNA\n                    <i>UCA1<\/i>\n                    Increases Proliferation and Multidrug Resistance of Retinoblastoma Cells Through Downregulating miR-513a-5p"],"prefix":"10.1177","volume":"39","author":[{"given":"Lidong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ocular Fundus Disease, Cangzhou Eye Hospital, Cangzhou Central Hospital, Cangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ocular Fundus Disease, Cangzhou Eye Hospital, Cangzhou Central Hospital, Cangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ocular Fundus Disease, Cangzhou Eye Hospital, Cangzhou Central Hospital, Cangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ocular Fundus Disease, Cangzhou Eye Hospital, Cangzhou Central Hospital, Cangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"e_1_3_3_2_1","article-title":"Clinical application of long non-coding RNA-UCA1 as a candidate gene in progression of esophageal cancer","author":"Aalijahan H.","year":"2019","unstructured":"Aalijahan H., , and Ghorbian S. 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