{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:23:44Z","timestamp":1791559424627,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>\n                    Competing endogenous RNAs (ceRNAs), including long noncoding RNA (lncRNA), circular RNA (circRNA), pseudogenes, synthetic miRNA inhibitors, etc. are classes of RNAs that can compete and interact with each other within an organism. There are regions in these RNAs that can be bound by messenger-RNA-interfering complementary RNA (microRNA), called microRNA response elements (MREs). These RNAs compete with each other to combine complementary microRNAs and MREs to form ceRNA regulatory mechanisms and participate in the regulation of many biological processes. The oxidative stress injury of melanocytes is one of the crucial mechanisms of vitiligo. However, it is unclear whether the ceRNA regulation mechanism is involved in the oxidative stress injury of melanocytes. The purpose of this study is to explore the changes of messenger RNA (mRNA), lncRNAs, and circRNAs in melanocytes under oxidative stress and to identify the key ceRNA regulatory networks. Compared with the normal cells, the chip detection of ceRNA expression profile showed that the expression of 491 mRNAs, 865 lncRNAs, and 1161 circRNAs were altered more than fivefold during the oxidative stress injury of melanocytes. The oxidative stress-related genes (\n                    <jats:italic toggle=\"yes\">SOD2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">PTGS2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">DHFR<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">HMOX1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">FOSL1<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">PARP1<\/jats:italic>\n                    ), cell cycle-related genes (\n                    <jats:italic toggle=\"yes\">CDK1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CCNB1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">CCNA2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">OIP5<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">MK167<\/jats:italic>\n                    ), and apoptosis-related gene (\n                    <jats:italic toggle=\"yes\">BIRC5<\/jats:italic>\n                    ) were identified in the formation of ceRNA regulation networks with lncRNAs and circRNAs, which shares the common MREs. Further verification found that LNCV6_120941_PI430048170 or hsa_circ_0048910 might regulate the expression of\n                    <jats:italic toggle=\"yes\">SOD2<\/jats:italic>\n                    by sponging hsa-miR-4755-3p, LNCV6_119109_PI430048170, or hsa_circ_0048909 might regulate the expression of\n                    <jats:italic toggle=\"yes\">HMOX1<\/jats:italic>\n                    by sponging hsa-miR-6721-5p in the oxidative stress injury of melanocytes. In conclusion, complex changes of the ceRNA regulatory network in the oxidative stress response of melanocytes are evident. Oxidative stress may mediate melanocyte injury through the ceRNA regulation mechanism and induce the pathogenesis of vitiligo.\n                  <\/jats:p>","DOI":"10.1089\/dna.2020.5455","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T15:44:44Z","timestamp":1611157484000},"page":"192-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Identification of the Competing Endogenous RNA Networks in Oxidative Stress Injury of Melanocytes"],"prefix":"10.1177","volume":"40","author":[{"given":"Si","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.3126\/kumj.v12i2.13660"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.12.007"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12952"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8622-7"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105734"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409594102"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3155"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.04.131"},{"key":"e_1_3_6_11_1","first-page":"2523","article-title":"DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2\/HO-1 axis","volume":"43","author":"Clementi M.E.","year":"2019","unstructured":"Clementi M.E., , Lazzarino G., , Sampaolese B., , Brancato A., , and Tringali G. 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