{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:47Z","timestamp":1792686467746,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2022,6,1]]},"DOI":"10.1089\/dna.2021.1182","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T16:23:42Z","timestamp":1652977422000},"page":"617-630","source":"Crossref","is-referenced-by-count":21,"title":["Rutin Inhibits the Progression of Osteoarthritis Through\n                    <i>CBS<\/i>\n                    -Mediated\n                    <i>RhoA\/ROCK<\/i>\n                    Signaling"],"prefix":"10.1177","volume":"41","author":[{"given":"Cong","family":"Sui","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyue","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-422X","authenticated-orcid":false,"given":"Yong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China."},{"name":"Department of Orthopedics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.20472"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.111"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161006144942"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-019-01823-w"},{"key":"B5","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.4103\/1673-5374.121709","volume":"8","author":"Chen K.","year":"2013","journal-title":"Neural Regen Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2174\/1389201021666200212093130"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203470"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.05.032"},{"key":"B9","first-page":"5324","volume":"11","author":"Deng Z.","year":"2019","journal-title":"Am J Transl Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.107"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2016.04.025"},{"key":"B12","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","volume":"392","author":"GBD 2017 Risk Factor Collaborators","year":"2018","journal-title":"Lancet"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2019.03.004"},{"key":"B14","first-page":"683","volume":"56","author":"Guardia T.","year":"2001","journal-title":"Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.08.016"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-021-00485-4"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102670"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100505"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.703670"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21257"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000201960.04223.3c"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/art.37922"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00075-9"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107624"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071648"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101772"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.04.003"},{"key":"B29","first-page":"169","volume":"13","author":"Quadir H.","year":"2021","journal-title":"Cureus"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-01142-x"},{"key":"B31","first-page":"155","volume":"21","author":"Stefik D.","year":"2021","journal-title":"Bosn J Basic Med Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00164-y"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311427200"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-110859"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.12.057"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1159\/000484162"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9917-9"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.723988"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00014.2020"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126452"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00674"}],"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/dna.2021.1182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/dna.2021.1182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:59:47Z","timestamp":1777399187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/dna.2021.1182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"alternative-id":["10.1089\/dna.2021.1182"],"URL":"https:\/\/doi.org\/10.1089\/dna.2021.1182","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}