{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:42:40Z","timestamp":1777552960812,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    Nonsyndromic cleft lip with or without cleft palate (NSCL\/P) is a common craniofacial birth defect with complex etiologies. Recently, the dysregulation of long noncoding RNAs (lncRNAs) has been implicated in many developmental diseases, including NSCL\/P. However, the functions and mechanisms of lncRNAs in NSCL\/P have not been fully elucidated. In this study, we found that lncRNA\n                    <jats:italic toggle=\"yes\">MIR31HG<\/jats:italic>\n                    in NSCL\/P patients was significantly downregulated than that in healthy individuals (GSE42589, GSE183527). In addition, single nucleotide polymorphism rs58751040 in\n                    <jats:italic toggle=\"yes\">MIR31HG<\/jats:italic>\n                    was nominally associated with NSCL\/P susceptibility (odds ratio: 1.29, 95% confidence interval: 1.03\u20131.54,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20094.93\u2009\u00d7\u200910\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) through a case\u2013control study (504 NSCL\/P cases and 455 controls). Luciferase activity assay showed that the C allele of rs58751040 revealed a decreased transcription activity of\n                    <jats:italic toggle=\"yes\">MIR31HG<\/jats:italic>\n                    than the G allele. Moreover, knockdown of\n                    <jats:italic toggle=\"yes\">MIR31HG<\/jats:italic>\n                    promoted cell proliferation and migration in human oral keratinocytes and human embryonic palate mesenchyme. Bioinformatic analysis and cellular studies suggested that\n                    <jats:italic toggle=\"yes\">MIR31HG<\/jats:italic>\n                    may confer susceptibility to risk of NSCL\/P through matrix Gla protein (\n                    <jats:italic toggle=\"yes\">MGP<\/jats:italic>\n                    ) signaling. In summary, we identified a novel lncRNA involved in the development of NSCL\/P.\n                  <\/jats:p>","DOI":"10.1089\/dna.2022.0657","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T11:43:12Z","timestamp":1686915792000},"page":"390-398","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["lncRNA\n                    <i>MIR31HG<\/i>\n                    Regulates Proliferation and Migration by Targeting Matrix Gla Protein in Nonsyndromic Cleft Lip With or Without Cleft Palate"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-9430","authenticated-orcid":false,"given":"Xiaofeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-1919","authenticated-orcid":false,"given":"Xinze","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-7677","authenticated-orcid":false,"given":"Yue","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guirong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China."},{"name":"Department of Stomatology, Medical Center of Soochow University, Suzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China."},{"name":"Jiangsu Province Key Laboratory of Oral Diseases, Nanjing, China."},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.12.011"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.333"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26830"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22090"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1677551"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.662780"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.03.001"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110313"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618676114"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay5525"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdev.2021.203656"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-017-0403-x"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdev.2021.203674"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.12.012"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.07.013"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.014"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1903"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400350111"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.011"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110382"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2021.01.017"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00576"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1022"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.769802"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.08.021"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12758"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002165"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.110544"},{"issue":"7","key":"e_1_3_6_30_1","first-page":"S11","article-title":"Global birth prevalence of orofacial clefts: A systematic review","volume":"98","author":"Panamonta V","year":"2015","unstructured":"Panamonta V, , Pradubwong S, , Panamonta M, et al. Global birth prevalence of orofacial clefts: A systematic review. J Med Assoc Thai, 2015; 98 Suppl 7:S11\u2013S21.","journal-title":"J Med Assoc Thai"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003536"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.06.147"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0916-8"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23859"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.06.107"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3568"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6254308"}],"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dna.2022.0657","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2022.0657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2022.0657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:00:03Z","timestamp":1777399203000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dna.2022.0657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1089\/dna.2022.0657"],"URL":"https:\/\/doi.org\/10.1089\/dna.2022.0657","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}