{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:41:45Z","timestamp":1777552905809,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    Genomic imprinting refers to the expression of parent-specific genes in diploid mammalian cells.\n                    <jats:italic toggle=\"yes\">MAGEL2<\/jats:italic>\n                    gene is a maternally imprinted gene that has been identified in mice and humans and is associated with the onset of puberty. The purpose of this study was to investigate its imprinting status and its relationship with the onset of puberty in Dolang sheep. The sequence of 3734\u2009bp cDNA of\n                    <jats:italic toggle=\"yes\">MAGEL2<\/jats:italic>\n                    in Dolang sheep was obtained by cloning and sequencing, encoding 1173 amino acids. The results of the nucleotide and amino acid similarity analysis showed that it was highly conserved among different mammalian species. The\n                    <jats:italic toggle=\"yes\">MAGEL2<\/jats:italic>\n                    gene was expressed monoallelically in the tissues of adult and neonatal umbilical cords, and the expressed allele was paternally inherited. Real Time quantitative PCR (RT-qPCR) results showed that the\n                    <jats:italic toggle=\"yes\">MAGEL2<\/jats:italic>\n                    gene was highly expressed in the hypothalamus and pituitary gland, increased significantly from prepuberty to puberty, and decreased significantly after puberty. This study suggests that\n                    <jats:italic toggle=\"yes\">MAGEL2<\/jats:italic>\n                    is a paternally expressed and maternally imprinted gene in Dolang sheep, which may be involved in the initiation of puberty in Dolang sheep. This study provides a theoretical basis for further research on the mechanism of the imprinted gene\n                    <jats:italic toggle=\"yes\">MAGEL2<\/jats:italic>\n                    regulating the onset of puberty in sheep, and provides a new idea for the future research on the mechanism of onset of puberty in sheep.\n                  <\/jats:p>","DOI":"10.1089\/dna.2023.0166","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:44:23Z","timestamp":1697456663000},"page":"689-696","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of the Imprinting Status and Expression of the\n                    <i>MAGEL2<\/i>\n                    Gene During Initiation at Puberty in the Dolang Sheep"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-4258","authenticated-orcid":false,"given":"Yongjie","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Tarim University, Xinjiang Production and Construction Corps, Alar, China."},{"name":"Key Laboratory of Tarim Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-8723","authenticated-orcid":false,"given":"Zhiyuan","family":"Sui","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Tarim University, Xinjiang Production and Construction Corps, Alar, China."},{"name":"Key Laboratory of Tarim Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhishuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Tarim University, Xinjiang Production and Construction Corps, Alar, China."},{"name":"Key Laboratory of Tarim Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenguang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Tarim University, Xinjiang Production and Construction Corps, Alar, China."},{"name":"Key Laboratory of Tarim Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Tarim University, Xinjiang Production and Construction Corps, Alar, China."},{"name":"Key Laboratory of Tarim Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Tarim University, Xinjiang Production and Construction Corps, Alar, China."},{"name":"Key Laboratory of Tarim Animal Husbandry Science and Technology, Xinjiang Production and Construction Corps, Alar, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302160"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jora.12385"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002592"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.13.2497"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23347"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.138576"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12111550"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201502"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2018.1503489"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/85927"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2022.01.001"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0719-0"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-007-9039-z"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.12.1813"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab155"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11071985"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400963"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359901050"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003207"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004291"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03197-z"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.745048"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13545"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111094"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.05.012"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0709"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-animal-022513-114144"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.18.0276"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1266\/ggs.87.53"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.818810"}],"container-title":["DNA and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/dna.2023.0166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2023.0166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/dna.2023.0166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:59:54Z","timestamp":1777399194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/dna.2023.0166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1089\/dna.2023.0166"],"URL":"https:\/\/doi.org\/10.1089\/dna.2023.0166","relation":{},"ISSN":["1044-5498","1557-7430"],"issn-type":[{"value":"1044-5498","type":"print"},{"value":"1557-7430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}