{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:46:28Z","timestamp":1777589188561,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      Ureteral stenting is a widely used method for noninvasive urinary drainage in ureteral obstruction. However, biofilm development due to transient bacteriuria can cause severe complications such as incrustation with subsequent obstruction as well as recurrent urinary tract infection. Apart from local ailment such as dysuria, this increases both stent replacement frequency and incidence of complications. In this work, we investigated\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      the bacterial adhesion to a surface-attached and cross-linked poly(N,N-dimethylacrylamide) (PDMAA) hydrogel network, which is known for its nonfouling and protein-repellent characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      To mimic the conditions encountered\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      , PDMAA-coated and uncoated cyclic olefin polymer (COP) slides as well as polyurethane (PU)-coated glass slides were incubated in sterile human urine for 48 hours. Colonization was then simulated by adding known uropathogens, cultivated from clinical urine samples (such as\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      ). After further incubation for 24 and 48 hours, slides were washed, and the remaining adherent bacteria were solubilized by ultrasound. CFUs were counted after plating and incubation for 48 hours of the resulting solution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      PDMAA reduced adherent\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      about fivefold on coated PU glass slides as well as in PDMAA-coated COP slides. With adherent\n                      <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      there was a tendency to decreased biofilm formation, but the difference was not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      PDMAA reduces surface adherence of the most common uropathogen significantly. Assessment of clinical relevance and of the effect on further uropathogens needs further experimental and clinical evaluations.\n                      <jats:italic toggle=\"yes\">German Clinical Trial Register ID:<\/jats:italic>\n                      DRKS00013264 (approved WHO primary register).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2018.0616","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T19:48:42Z","timestamp":1542743322000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>In Vitro<\/i>\n                    Effects of a Novel Coating Agent on Bacterial Biofilm Development on Ureteral Stents"],"prefix":"10.1177","volume":"33","author":[{"given":"Tamas","family":"Szell","sequence":"first","affiliation":[{"name":"Medical Center\u2013University of Freiburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz Friedrich","family":"Dressler","sequence":"additional","affiliation":[{"name":"Medical Center\u2013University of Freiburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Goelz","sequence":"additional","affiliation":[{"name":"Medical Center\u2013University of Freiburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Bluemel","sequence":"additional","affiliation":[{"name":"Medical Center\u2013University of Freiburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkadiusz","family":"Miernik","sequence":"additional","affiliation":[{"name":"Medical Center\u2013University of Freiburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Brandstetter","sequence":"additional","affiliation":[{"name":"University of Freiburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Scherag","sequence":"additional","affiliation":[{"name":"University of Freiburg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik Stefan","family":"Schoeb","sequence":"additional","affiliation":[{"name":"Medical Center\u2013University of 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