{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:46:58Z","timestamp":1792025218290,"version":"4.4.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      To compare the safety and efficacy of holmium laser enucleation of prostate (HoLEP)\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      bipolar plasmakinetic resection of prostate (BPRP) in the management of large-sized (\u226575\u2009g) benign prostatic hyperplasia (BPH).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This randomized-controlled trial recruited 145 symptomatic BPH patients who had failed medical management, and who had undergone either HoLEP (Versa pulse\n                      <jats:sup>\u00ae<\/jats:sup>\n                      100 W;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200973) or BPRP (AUTOCON\n                      <jats:sup>\u00ae<\/jats:sup>\n                      II 400 ESU;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200972). Both groups were compared using the Mann\u2013Whitney, chi-square, Student-\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      , or Fisher exact tests as appropriate. Preoperative\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      postoperative findings (24 months) were compared using paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test or Wilcoxon signed-rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The two groups were comparable for most preoperative findings including prostate size (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.629), although HoLEP included more patients on anticoagulants (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). HoLEP was associated with significantly less operative duration (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hemoglobin loss (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), catheterization duration (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.009), and hospital stay (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was no significant difference in total complications (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.291) and each separate complication. Blood transfusion was reported only with BPRP (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.058). At 24 months of follow-up, there was significant improvement in all the parameters in each group (International Prostate Symptom Score [IPSS], maximum urinary flow rate [Q\n                      <jats:sub>max<\/jats:sub>\n                      ]\n                      <jats:sub>,<\/jats:sub>\n                      quality of life [QoL], and postvoid residual urine [PVRU];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was no significant difference between both groups in postoperative IPSS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.08), Q\n                      <jats:sub>max<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.051), QoL (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.057), or PVRU (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.069). There was significantly better percentage improvement of both IPSS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006) and QoL (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.025) in HoLEP. HoLEP and smaller removed (resected or enucleated) tissues were associated with a reduction in the primary outcomes (hemoglobin loss and operative duration) in logistic regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      HoLEP showed better safety profile with significantly less operative duration, hemoglobin loss, hospital stay, and catheterization duration. Although both procedures were effective, HoLEP showed significantly better percentage improvement of both IPSS and QoL.\n                      <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:uri>\n                      Identifier: NCT04143399.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2020.0636","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T02:50:51Z","timestamp":1598410251000},"page":"171-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Holmium Laser Enucleation Versus Bipolar Plasmakinetic Resection for Management of Lower Urinary Tract Symptoms in Patients with Large-Volume Benign Prostatic Hyperplasia: Randomized-Controlled Trial"],"prefix":"10.1177","volume":"35","author":[{"given":"Enmar Ibrahim","family":"Habib","sequence":"first","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Said","family":"ElSheemy","sequence":"additional","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Hossam","sequence":"additional","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Morsy","sequence":"additional","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein Aly","family":"Hussein","sequence":"additional","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Yehia","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Salah","family":"Abdelazim","sequence":"additional","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Fathy","sequence":"additional","affiliation":[{"name":"Urology Department, Kasr Al-Ainy Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05253.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2007.0005"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000086948.55973.00"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000140501.68841.a1"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-015-1735-9"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.02.032"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.087"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2011.0059"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.08.004"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2017.0700"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02890-9"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2353-0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2019.0707"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.06.025"}],"container-title":["Journal of Endourology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/end.2020.0636","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/end.2020.0636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/end.2020.0636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:18:06Z","timestamp":1777407486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/end.2020.0636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1089\/end.2020.0636"],"URL":"https:\/\/doi.org\/10.1089\/end.2020.0636","relation":{},"ISSN":["0892-7790","1557-900X"],"issn-type":[{"value":"0892-7790","type":"print"},{"value":"1557-900X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}