{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:51:08Z","timestamp":1788691868287,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The bladder cuff (BC) management and its surgical approach represent an essential and debated step in radical nephroureterectomy (RNU) for upper tract urothelial carcinoma. The objective of our study was to determine which BC management has the best oncologic outcomes in terms of bladder recurrence-free survival (BRFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analyzed all patients who underwent an open robot-assisted laparoscopic (RNU) or a combined RNU between March 2012 and March 2019 in three academic hospitals. BC management approaches were divided into two categories: (O-cuff) open BC and (R-cuff) robot-assisted BC. We assessed demographic characteristics, distal ureter approach, pathology, and operative details, as well as oncologic outcomes including BRFS. Survival was analyzed using the Kaplan\u2013Meier method and compared using the log-rank test. A multivariable analysis was performed to identify predictive factors of bladder recurrence (BR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 117 patients were included with a mean follow-up of 40.4 months. Patients with a history of bladder cancer, RNU with pure laparoscopic approach, and endoscopic BC were excluded. There were 53 (45%) patients in the O-cuff group and 64 (55%) in the R-cuff group. BRFS at 2 years was 73.3% and 72.7% for O-cuff and R-cuff, respectively (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.9). On multivariable analysis, distal ureter tumor (odds ratio: 6.24, 95% confidence interval: 1.95\u201321.5;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) was associated with BR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was no statistically significant difference in BRFS between the O-cuff and R-cuff groups. Nevertheless, we underlined that distal ureter tumor was associated with BR. Although we did not find differences regarding the surgical approach, BC remains a very important step of RNU and caution should be taken when performed laparoscopically to avoid any tumor spillage. Risk factors for bladder cancer recurrence might be taken into account for the choice of its surgical approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2021.0303","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T02:42:20Z","timestamp":1623638540000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Management of Distal Ureter During Radical Nephroureterectomy Does Not Influence Bladder Recurrence"],"prefix":"10.1177","volume":"36","author":[{"given":"Marina","family":"Pizzighella","sequence":"first","affiliation":[{"name":"Department of Urology, CHU Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Bruy\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU Tours, Tours, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Peyronnet","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU Rennes, Rennes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Graffeille","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU Rennes, Rennes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Brichart","sequence":"additional","affiliation":[{"name":"Department of Urology, CHR Orl\u00e9ans, Orl\u00e9ans, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Urology, The Jikei University School of Medicine, Tokyo, Japan."},{"name":"Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Verhoest","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU Rennes, Rennes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Bensalah","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU Rennes, Rennes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Moschini","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology, Department of Urology, Urological Research Institute, Vita-Salute San Raffaele University, Milano, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evenguelos","family":"Xylinas","sequence":"additional","affiliation":[{"name":"Urology Department, Bichat-Claude Bernard Hospital, Assistance-Publique H\u00f4pitaux de Paris, Paris University, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-8558","authenticated-orcid":false,"given":"Benjamin","family":"Pradere","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU Tours, Tours, France."},{"name":"Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the European Association of Urology Young Academic Urologists Urothelial Carcinoma Working Group (EAU YAU)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.05.042"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.042"},{"key":"e_1_3_4_5_2","first-page":"32","article-title":"Systematic review of open versus laparoscopic versus robot-assisted nephroureterectomy","volume":"19","author":"Mullen E","year":"2017","unstructured":"Mullen E, , Ahmed K, , Challacombe B. Systematic review of open versus laparoscopic versus robot-assisted nephroureterectomy. Rev Urol, 2017; 19:32\u201343.","journal-title":"Rev Urol"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1819-1"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2018.0819"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.12.075"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2017.0086"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.052"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.07.003"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.06.016"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.009"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_3_4_15_2","unstructured":"8th Edition of the UICC TNM classification of Malignant Tumors published | UICC. https:\/\/www.uicc.org\/news\/8th-edition-uicc-tnm-classification-malignant-tumors-published. Accessed March7 2020."},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-03020-1"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.06.013"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2128"},{"key":"e_1_3_4_19_2","first-page":"3821","article-title":"Clipping the extremity of ureter prior to nephroureterectomy is effective in preventing subsequent bladder recurrence after upper urinary tract urothelial carcinoma","volume":"125","author":"Chen M-K","year":"2012","unstructured":"Chen M-K, , Ye Y-L, , Zhou F-J, et al. Clipping the extremity of ureter prior to nephroureterectomy is effective in preventing subsequent bladder recurrence after upper urinary tract urothelial carcinoma. Chin Med J (Engl), 2012; 125:3821\u20133826.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12121"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.11.035"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.003"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.06.003"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.064"}],"container-title":["Journal of Endourology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/end.2021.0303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/end.2021.0303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/end.2021.0303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:18:55Z","timestamp":1777407535000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/end.2021.0303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1089\/end.2021.0303"],"URL":"https:\/\/doi.org\/10.1089\/end.2021.0303","relation":{},"ISSN":["0892-7790","1557-900X"],"issn-type":[{"value":"0892-7790","type":"print"},{"value":"1557-900X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}