{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:25:09Z","timestamp":1780320309232,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Apart from the existing level-one evidence, few centers have reported on long-term outcomes after Holmium Laser Enucleation of the Prostate (HoLEP). Against this backdrop we aimed to report on our treatment experience and identify predictors of persistent\/recurrent lower urinary tract symptoms (LUTS) after the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>From 2006 to 2017, 2566 men underwent HoLEP at our institution. Only patients with available, cross-sectional follow-up (F\/u) \u22656 months were included. Perioperative and F\/u characteristics were compared by duration of F\/u in months (quartiles). Multivariable logistic regression models (MVAs) were used to identify predictors of persistent\/recurring symptoms, defined as International Prostate Symptom Score (IPSS) &gt;7 at F\/u.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 774 patients with a median age of 70 years (interquartile range [IQR]\u2009=\u200966\u201375), prostate volume of 80\u2009mL (IQR\u2009=\u200960\u2013105), American Society of Anesthesiologists score 2 (IQR\u2009=\u20092\u20133), IPSS of 19 (IQR\u2009=\u200914\u201324), and quality of life (QoL) of 4 (3\u20135) at the time of operation were analyzed. Median F\/u was 52 months (IQR\u2009=\u200932\u201377), overall current median prostate-specific antigen was 0.91\u2009mg\/dL (0.5\u20131.8), median IPSS and QoL were 3 (IQR\u2009=\u20091\u20137) and 1 (IQR 0\u20132), respectively. LUTS medication was present in 20 patients (2.6%), 15 (2%) patients required reoperation, and permanent urinary incontinence was present in 17 (2.2%) patients. On MVA age at operation (odds ratio [OR]\u2009=\u20091.04; 95% confidence interval [CI], 1.01\u20131.1;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.013), prostate volume (OR\u2009=\u20090.99 [95% CI, 0.98\u20130.99;],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003), body mass index (OR\u2009=\u20091.06 [95% CI, 1.0\u20131.1],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.043), presence of indwelling catheter (OR\u2009=\u20090.51 [95% CI, 0.32\u20130.81],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004), and anticholinergics before procedure (OR\u2009=\u20091.74 [95% CI, 1.01\u20133.0],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.046) were predictors of persistent\/recurring symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our HoLEP experience confirms durable and profound symptom relief in the vast majority men. A small fraction of patients complained about subjective persistent\/recurring LUTS stressing the need for proper patient selection and timing of surgical intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2022.0396","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T01:48:18Z","timestamp":1668044898000},"page":"316-322","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Which Men Do or Do Not Achieve Long-Term Symptom Relief After Holmium Laser Enucleation of the Prostate (HoLEP): 11 Years of HoLEP Experience"],"prefix":"10.1177","volume":"37","author":[{"given":"Philipp","family":"Gild","sequence":"first","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-3883","authenticated-orcid":false,"given":"Malte W.","family":"Vetterlein","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim A.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Soave","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix K.-H.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Frankfurt, Frankfurt, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Ahyai","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University Graz, Graz, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Dahlem","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Fisch","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rink","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."},{"name":"Department of Urology, Ruhr-University Bochum, Herford Hospital, Herford, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Urology, University Medical Center Frankfurt, Frankfurt, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2016.04.001"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12794"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00908.x"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.058"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.08.036"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042307-199801000-00003"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1443-x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.06.017"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000280"},{"key":"e_1_3_4_11_2","author":"Fallara G","unstructured":"Fallara G, , Capogrosso P, , Schifano N, et al. 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