{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:42:29Z","timestamp":1777588949255,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess the ability to deliver full-thickness bladder wall cryoablation through a cystoscopic approach using a new closed-loop 6F cryocatheter and thermal dose-controlled protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Evaluations were conducted using a chronic porcine model wherein 10 lesions\/animal were created throughout the bladder (bladder wall, trigone region, ureteral orifice, and distal ureter). A 6F cryocatheter was passed through the working channel of a flexible cystoscope. Single 1- and 1.5-minute freeze protocols in a saline environment were evaluated and resultant lesion size was determined. A laparoscopic approach was utilized to observe the transmural extension of the ice propagation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Studies demonstrated the generation of transmural lesions characterized by full-thickness histologic necrosis after freezing for 1.5 minutes regardless of tissue thickness (range 2\u201312\u2009mm). All animals were found to have good overall health (maintained weight, appetite, mobility, and energy levels) throughout the recovery period. No significant deviations were noted in complete blood count and serum chemistry bloodwork except for elevated creatine kinase levels. Importantly, no fistulas or perforations were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The cryocatheter was able to rapidly and effectively freeze the bladder wall through a cystoscopic approach. The results showed the ability to consistently ablate an \u223c1\u2009cm diameter and up to 1.2\u2009cm deep using a single 1.5-minute freeze protocol. Analysis of the ablation efficacy revealed \u223c80% destruction within the frozen mass. Although further testing and refinement are needed, these studies demonstrate the potential of this new approach to provide a next-generation strategy for the treatment of bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2023.0635","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T07:47:15Z","timestamp":1706341635000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of a New Cystoscopic Cryocatheter and Method for the\n                    <i>In Situ<\/i>\n                    Destruction of Bladder Cancer: Preliminary\n                    <i>In Vivo<\/i>\n                    Study"],"prefix":"10.1177","volume":"38","author":[{"given":"John M.","family":"Baust","sequence":"first","affiliation":[{"name":"CPSI Biotech, Research &amp; Development, Owego, New York, USA."},{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Department of Urology, NYU Langone Hospital Long Island, Mineola, New York, USA."},{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Robilotto","sequence":"additional","affiliation":[{"name":"CPSI Biotech, Research &amp; Development, Owego, New York, USA."},{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Urology, NYU Langone Hospital Long Island, Mineola, New York, USA."},{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Santucci","sequence":"additional","affiliation":[{"name":"CPSI Biotech, Research &amp; Development, Owego, New York, USA."},{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Van Buskirk","sequence":"additional","affiliation":[{"name":"CPSI Biotech, Research &amp; Development, Owego, New York, USA."},{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."},{"name":"Center for Translational Stem Cell and Tissue Engineering, Binghamton University, Binghamton, New York, USA."},{"name":"Department of Biological Sciences, Binghamton University, Binghamton, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Baust","sequence":"additional","affiliation":[{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."},{"name":"Center for Translational Stem Cell and Tissue Engineering, Binghamton University, Binghamton, New York, USA."},{"name":"Department of Biological Sciences, Binghamton University, Binghamton, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi K.","family":"Snyder","sequence":"additional","affiliation":[{"name":"CPSI Biotech, Research &amp; Development, Owego, New York, USA."},{"name":"Vesana, Inc., Research &amp; Development, Owego, New York, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"Bladder Cancer Statistics. World Cancer Research Fund; 2020. Available from: www.wcrf.org [Last accessed: October31 2023]."},{"key":"e_1_3_6_3_2","unstructured":"Survival Rates for Bladder Cancer. 2017. Available from: https:\/\/www.cancer.org\/cancer\/bladder-cancer\/detection-diagnosis-staging\/survival-rates.html [Last accessed: November23 2022]."},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2018.06.006"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2019.06.002"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2016.1126515"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2014.08.006"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2013.12.004"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2016.05.002"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2012.0696"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12216"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2007.07.003"},{"key":"e_1_3_6_13_2","doi-asserted-by":"crossref","unstructured":"Baust JM Robilotto AT Gage AA Baust JG. 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