{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:02:52Z","timestamp":1790290972335,"version":"4.1.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The use of a ureteral access sheath (UAS) during ureteroscopy (URS) has been associated with the risk for ureteral injuries. Preoperative administration of \u03b11-blockers presents a potential mitigator of such lesions by inducing ureteral relaxation, which may also contribute to improving other surgical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search was conducted across MEDLINE, Embase, and Cochrane databases for studies comparing preoperative \u03b11-blockers administration\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      its non-use in adult patients without pre-stenting undergoing URS. Binary outcomes were evaluated using risk ratios (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity was measured with the Cochran\u2019s Q test,\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistics, and prediction intervals (PIs). A DerSimonian and Laird random-effects model was utilized for all outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eleven studies encompassing 1074 patients undergoing URS were included, of whom 522 (48.60%) received \u03b11-blockers before the procedure. Preoperative \u03b11-blockers were associated with a reduction in significant ureteral injuries (RR 0.30; 95% CI 0.17\u20130.53;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 6%; PI 0.10\u20130.88) and an increase in mean successful UAS insertion (OR 2.14; 95% CI 1.08\u20134.23;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 23%; PI 0.51\u20138.93). In patients undergoing exclusively ureteroscopy lithotripsy (URSL), the medications also reduced total complications (RR 0.62; 95% CI 0.46\u20130.84;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0%) and complications graded Clavien\u2013Dindo III or higher (RR 0.16; 95% CI 0.04\u20130.69;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0%), but no significant difference between groups was found in the stone-free rate (RR 1.10; 95% CI 0.86\u20131.40;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 91%; PI 0.47\u20132.59).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Preoperative \u03b11-blockers were linked to a decrease in significant ureteral injuries with UAS use and fewer complications during URSL procedures. However, their impact on the successful insertion of a UAS remains uncertain. Consideration of administering preoperative \u03b11-blockers in non-stented adult patients undergoing URS with UAS is advisable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2024.0060","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:12:14Z","timestamp":1715929934000},"page":"936-947","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Preoperative \u03b11-Blockers Impact on Outcomes of Patients Undergoing Ureteroscopy with Ureteral Access Sheaths: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-347X","authenticated-orcid":false,"given":"David Romeiro","family":"Victor","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences, Universidade de Pernambuco, Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael de Albuquerque Pereira de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universit\u00e1rio Oswaldo Cruz, Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Vieira Lima Aguiar","family":"Mel\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Urology, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Guimar\u00e3es Barbosa","family":"Coelho","sequence":"additional","affiliation":[{"name":"Medical School, Universidade Federal de Pernambuco, Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thom\u00e9 D\u00e9cio Pinheiro","family":"Barros J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universidade Federal de Pernambuco, Recife, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,1]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)59675-5"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-019-0489-x"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193600"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.271"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.01.021"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-4295(02)01948-9"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/089277904322836631"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.197"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2015.0294"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-017-2035-3"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2519-9"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2010.0400"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167670"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.313.6759"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008509.pub3"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2012.0227"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010247"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.09.173"},{"issue":"1","key":"e_1_3_5_23_2","first-page":"47","article-title":"Does preoperative use of silodosin affect the stages of F-URS procedure","volume":"73","author":"K\u00f6pr\u00fc B","year":"2020","unstructured":"K\u00f6pr\u00fc B, , Ebilo\u011flu T, , Kaya E, et al. 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