{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:21:50Z","timestamp":1791357710490,"version":"4.3.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Sepsis is the most serious complication of flexible ureteroscopy (F-URS) and laser lithotripsy. We assessed the influence of positive stone culture (SC) on major infectious complications (sepsis, septic shock).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective study enrolled adult patients deemed suitable for F-URS and laser lithotripsy from nine centers (January 2022\u2013August 2023). Inclusion criteria were as follows: kidney stone(s), preoperative midstream urine culture (MSUC), stone(s) assessed at computed tomography scan, and SC. Exclusion criteria were as follows: bilateral procedures, ureteral stones, and children. Group 1 included patients with sterile SC. Group 2 included patients with positive SC. Data are presented as median (interquartile range). A multivariable logistic regression analysis was performed to evaluate factors associated with having a positive SC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 293 patients were included. Median age was 51.0 (24) years. There were 167 (57.0%) males. Group 2 included 32 (2.5%) patients. Group 2 patients were significantly older [75.0 (14)\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      51.0 (23) years,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02]. Stone features were similar. Major infectious complications were higher in Group 2 (15.6%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      0.4%). One patient died because of sepsis in Group 2. Two out of 6 (33.3%) patients with major infectious complications had the same pathogen in MSUC and SC. In the multivariable regression analysis, diabetes (OR 3.23), symptomatic urinary infections within 3 months before operation (OR 4.82) and preoperative stent\/nephrostomy (OR 2.92) were factors significantly associated with higher odds of positive SC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with positive SC have a higher incidence of major infectious complications after F-URS lithotripsy. SC should be performed whenever feasible because there is a poor correlation between MSUC and SC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2024.0182","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:32:19Z","timestamp":1718364739000},"page":"948-955","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The Significance of Stone Culture in the Incidence of Sepsis: Results from a Prospective, Multicenter Study on Infections Post Flexible UreteroreNescopy (I-FUN) and Laser Lithotripsy for Renal Stones"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-9190","authenticated-orcid":false,"given":"Daniele","family":"Castellani","sequence":"first","affiliation":[{"name":"Urology Unit, Azienda Ospedaliero-Universitaria delle Marche, Universit\u00e0 Politecnica delle Marche, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Brocca","sequence":"additional","affiliation":[{"name":"Urology Unit, Azienda Ospedaliero-Universitaria delle Marche, Universit\u00e0 Politecnica delle Marche, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgilio","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Urology Unit, Azienda Ospedaliero-Universitaria delle Marche, Universit\u00e0 Politecnica delle Marche, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Mazzon","sequence":"additional","affiliation":[{"name":"Urology Unit, ULSS, Bassano del Grappa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Celia","sequence":"additional","affiliation":[{"name":"Urology Unit, ULSS, Bassano del Grappa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bosio","sequence":"additional","affiliation":[{"name":"Department of Urology, Citt\u00e0 della Salute e della Scienza Molinette University Hospital, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauco","family":"Bertello","sequence":"additional","affiliation":[{"name":"Department of Urology, Citt\u00e0 della Salute e della Scienza Molinette University Hospital, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Alessandria","sequence":"additional","affiliation":[{"name":"Department of Urology, Citt\u00e0 della Salute e della Scienza Molinette University Hospital, Turin, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cormio","sequence":"additional","affiliation":[{"name":"Andrology and Urology Unit, \u201cL. Bonomo\u201d Hospital, Andria, Italy."},{"name":"School of Urology, University of Foggia, Foggia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runeel","family":"Ratnayake","sequence":"additional","affiliation":[{"name":"Andrology and Urology Unit, \u201cL. Bonomo\u201d Hospital, Andria, Italy."},{"name":"School of Urology, University of Foggia, Foggia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vismara Fugini","sequence":"additional","affiliation":[{"name":"Urology Unit, Fondazione Poliambulanza Hospital, Brescia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonino","family":"Morena","sequence":"additional","affiliation":[{"name":"Urology Unit, Fondazione Poliambulanza Hospital, Brescia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-5819","authenticated-orcid":false,"given":"Yiloren","family":"Tanidir","sequence":"additional","affiliation":[{"name":"Department of Urology, Marmara University School of Medicine, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik Emre","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Urology, Marmara University School of Medicine, Istanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9840-3366","authenticated-orcid":false,"given":"Simon","family":"Choong","sequence":"additional","affiliation":[{"name":"Institute of Urology, University College Hospitals of London, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-5632","authenticated-orcid":false,"given":"Stefania","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Modena and Reggio Emilia, Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pescuma","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Modena and Reggio Emilia, Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Micali","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Modena and Reggio Emilia, Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Pavan","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Stomatological Sciences, Urology Clinic, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alchiede","family":"Simonato","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Stomatological Sciences, Urology Clinic, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Gauhar","sequence":"additional","affiliation":[{"name":"Department of Urology, Ng Teng Fong General Hospital, Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Benedetto","family":"Galosi","sequence":"additional","affiliation":[{"name":"Urology Unit, Azienda Ospedaliero-Universitaria delle Marche, Universit\u00e0 Politecnica delle Marche, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04257-z"},{"key":"e_1_3_4_3_2","unstructured":"Skolarikos AA Neisius A Pet\u0159\u00edk A et al. 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