{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:05:44Z","timestamp":1789567544831,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endourology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Several complications of retrograde intrarenal surgery have been attributed to inadvertent increases in intrarenal pressure. We recently described the development of an innovative isoprenaline-eluting guidewire (IsoWire). The objective of this study was to investigate the impact of this IsoWire on the intrarenal pressure and evaluate its safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study was performed in 17 renal units using a porcine model. As controls, the intrarenal pressure, heart rate, and mean arterial pressure were measured for a duration of six minutes with a standard guidewire placed in the renal pelvis. For the experiment, the conventional guidewire was substituted with the IsoWire and the same parameters were measured. Blood samples were taken at one-minute intervals to measure plasma isoprenaline levels. This procedure was repeated on the opposite side.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean intrarenal pressure reduction was 29% (95% CI: 13%\u201353%). The mean isoprenaline effect time was 174 seconds. No changes in heart rate (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .908) or mean arterial pressure (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .749) were recorded after IsoWire insertion. Plasma isoprenaline levels were below the quantitation threshold. Isoprenaline concentrations in the plasma were below the quantification threshold. Ureteroscopy revealed no ureteral lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The IsoWire demonstrated a safe and effective reduction of intrarenal pressure. Additional research is necessary to determine whether ureteral smooth muscle relaxation generated by isoprenaline facilitates easier insertion of a ureteral access sheath, decreases the incidence of ureteral access sheath related ureteral lesions, or even encourage the practice of sheathless retrograde intrarenal surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/end.2024.0348","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T09:13:34Z","timestamp":1720862014000},"page":"1185-1191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacological Modulation of Intrarenal Pressure in a Porcine Model Using a Novel Isoprenaline-Eluting Guidewire"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-810X","authenticated-orcid":false,"given":"Jeff","family":"John","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa."},{"name":"Division of Urology, Department of Surgery, Frere Hospital and Walter Sisulu University, East London, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wellman","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-4976","authenticated-orcid":false,"given":"Tracy","family":"Kellermann","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Stellenbosch, Cape Town, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Kope\u0107","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioprocess Engineering, Laboratory of Biomedical Engineering, Warsaw University of Technology, Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Ciach","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioprocess Engineering, Laboratory of Biomedical Engineering, Warsaw University of Technology, Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Fieggen","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-735X","authenticated-orcid":false,"given":"Lisa","family":"Kaestner","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10495.x"},{"key":"e_1_3_5_3_2","volume-title":"EAU guidelines on Urolithiasis","author":"Skolarikos A, Hung H,","year":"2023","unstructured":"Skolarikos A, Hung H, , , Neisius A, et al. 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