{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:27:25Z","timestamp":1777642045425,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foodborne Pathogens and Disease"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Epidemiological data suggests that certain groups such as the elderly are more susceptible to listeriosis than the general population. Repeated exposure to low levels of\n                    <jats:italic toggle=\"yes\">Listeria monocytogenes<\/jats:italic>\n                    may increase the probability of infection. Increased susceptibility to infection in the elderly has been attributed in part to reduced activity of T cells. We investigated the impact of consecutive daily intragastric challenge with\n                    <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                    on the development of listeriosis within an aged guinea pig population. Approximately 63% of animals became infected following oral\n                    <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                    challenge with 10\n                    <jats:sup>4<\/jats:sup>\n                    \u2009CFU daily for 3 days, based on recovery of the pathogen from the liver or spleen. At day 4 postchallenge, 100% of animals were infected based on recovery of the bacterium in spleen and liver, decreasing to 14% by day 6 and then steadily increasing to 83% by day 13. During the 13-day postchallenge period, in the blood, numbers of total CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cells decreased significantly; CD8\n                    <jats:sup>+<\/jats:sup>\n                    T-cell population underwent two shifts; CD4\n                    <jats:sup>+<\/jats:sup>\n                    T-cell population decreased and then increased. The results suggest that listerial infection can occur following repeated daily exposure to low levels of\n                    <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                    and that during infection, CD3\n                    <jats:sup>+<\/jats:sup>\n                    T-cell immune response may be depressed, potentially increasing susceptibility to other diseases.\n                  <\/jats:p>","DOI":"10.1089\/fpd.2012.1292","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T14:22:33Z","timestamp":1363270953000},"page":"284-289","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Susceptibility of Aged Guinea Pigs to Repeated Daily Challenge with\n                    <i>Listeria monocytogenes<\/i>"],"prefix":"10.1177","volume":"10","author":[{"given":"Wen-Hsuan","family":"Wu","sequence":"first","affiliation":[{"name":"Rutgers University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl R.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Rutgers University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421702"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni804"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80540-3"},{"key":"e_1_3_3_5_1","unstructured":"[CDC] Centers for Disease Control and Prevention. Summary of notifiable diseases United States 2002. Morbid Mortal Weekly 2004; report 1\u201378."},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.9.5679"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360204"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2004.1.153"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2001.tb07011.x"},{"key":"e_1_3_3_10_1","doi-asserted-by":"crossref","unstructured":"Freitas RAJr. Nanomedicine Volume IIA: Biocompatibility. Georgetown TX: Landes Bioscience 2003.","DOI":"10.1201\/9781498712576"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01443-5"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1405.071395"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/biol.1997.0085"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00333-3"},{"key":"e_1_3_3_15_1","first-page":"25","article-title":"Age-associated changes in human T cell phenotype and function","volume":"6","author":"Jackola DR","year":"1994","unstructured":"Jackola DR, , Ruger JK, , Miller RA. Age-associated changes in human T cell phenotype and function. Aging, 1994; 6:25\u201334.","journal-title":"Aging"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6382"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.3956"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.1.1"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(01)00532-3"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(03)00326-X"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0505.990502"},{"key":"e_1_3_3_22_1","unstructured":"Meilgaard MC Civille GV Carr BT. Basic statistical methods. In: Sensory Evaluation Techniques. 4 th. Boca Raton FL: CRC Press 2006; 313\u2013355."},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81070-3"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(98)00185-8"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5271.70"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(200004)30:4<1053::AID-IMMU1053>3.0.CO;2-N"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/429324"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00221.x"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3402"},{"key":"e_1_3_3_30_1","first-page":"337","volume-title":"Listeria monocytogenes","author":"Rocourt J","year":"2007","unstructured":"Rocourt J, , Cossart P. Listeria monocytogenes. Doyle MP, , Beuchat LR. Washington, DC: Food Microbiology (ASM) Press, 2007; 337\u2013352."},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.P11101"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301273080407"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360211"},{"key":"e_1_3_3_34_1","doi-asserted-by":"crossref","unstructured":"[SOPBH] Scientific Opinion of the Panel on Biological Hazards on a request from the European Commission on Request for updating the former SCVPH opinion on Listeria monocytogenes risk related to ready-to-eat foods and scientific advice on different levels of Listeria monocytogenes in ready-to-eat foods and the related risk for human illness. EFSA J 2007; 599:1\u201342.","DOI":"10.2903\/j.efsa.2008.599"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082305"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765X.2002.01207.x"},{"key":"e_1_3_3_37_1","first-page":"188","article-title":"Surveillance of listeriosis in England and Wales 1995\u20131999","volume":"4","author":"Smerdon WJ","year":"2001","unstructured":"Smerdon WJ, , Jones R, , McLauchlin J, , Reacher M. Surveillance of listeriosis in England and Wales 1995\u20131999. Commun Dis Public Health, 2001; 4:188\u2013193.","journal-title":"Commun Dis Public Health"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/340248"},{"key":"e_1_3_3_39_1","first-page":"321","article-title":"The normalization of guinea pig leukocyte fractions and lymphocyte subsets in blood and lymphoid tissues using a flow cytometric procedure","volume":"53","author":"Takizawa M","year":"2004","unstructured":"Takizawa M, , Chiba J, , Haga S, , Asano T, , Yamamoto N, , Honda M. The normalization of guinea pig leukocyte fractions and lymphocyte subsets in blood and lymphoid tissues using a flow cytometric procedure. J Exp Anim Sci, 2004; 53:321\u2013329.","journal-title":"J Exp Anim Sci"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(96)00152-0"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-70.5.1122"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1086\/338465"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v35i5.18704"}],"container-title":["Foodborne Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/fpd.2012.1292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/fpd.2012.1292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/fpd.2012.1292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:22:03Z","timestamp":1777443723000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/fpd.2012.1292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1089\/fpd.2012.1292"],"URL":"https:\/\/doi.org\/10.1089\/fpd.2012.1292","relation":{},"ISSN":["1535-3141","1556-7125"],"issn-type":[{"value":"1535-3141","type":"print"},{"value":"1556-7125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}