{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:46:06Z","timestamp":1784335566390,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foodborne Pathogens and Disease"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    Chlorogenic acid (CA) has been reported to inhibit several pathogens, but the influence of subinhibitory concentrations of CA on virulence expression of pathogens has not been fully elucidated. The aim of this study was to explore the effect of CA on the virulence factor production of\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    . The minimum inhibitory concentration (MIC) of CA against\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    was determined using a broth microdilution method. Hemolysin assays, coagulase titer assays, adherence to solid-phase fibrinogen assays, Western blot, and real-time reverse transcriptase-polymerase chain reaction were performed to evaluate the effect of subinhibitory concentrations of CA on the virulence factors of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    . MIC of CA against\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    ATCC29213 was found to be 2.56\u2009mg\/mL. At subinhibitory concentrations, CA significantly inhibited the hemolysis and dose-dependently decreased coagulase titer. Reduced binding to fibrinogen and decreased production of SEA were observed with treatment of CA at concentrations ranging from 1\/16MIC to 1\/2MIC. CA markedly inhibited the expression of\n                    <jats:italic toggle=\"yes\">hla<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">sea<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">agr<\/jats:italic>\n                    genes in\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    . These data demonstrate that the virulence expression of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    could be reduced by CA and suggest that CA could be potentially developed as a supplemental strategy to control\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    infection and to prevent staphylococcal food poisoning.\n                  <\/jats:p>","DOI":"10.1089\/fpd.2013.1731","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T15:06:59Z","timestamp":1402067219000},"page":"677-683","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Effect of Subinhibitory Concentrations of Chlorogenic Acid on Reducing the Virulence Factor Production by\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1177","volume":"11","author":[{"given":"Guanghui","family":"Li","sequence":"first","affiliation":[{"name":"Northwest A&F University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Qiao","sequence":"additional","affiliation":[{"name":"Northwest A&F University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Northwest A&F University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Northwest A&F University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Northwest A&F University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Xia","sequence":"additional","affiliation":[{"name":"Northwest A&F University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2071751"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(97)00211-7"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2004.03.022"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.50-62.2006"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.2741\/cheung"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<1033::AID-JSFA595>3.0.CO;2-T"},{"key":"e_1_3_3_8_1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing 2005","author":"[CLSI] Clinical and Laboratory Standards Institute","year":"2005","unstructured":"[CLSI] Clinical and Laboratory Standards Institute. 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