{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:26:12Z","timestamp":1777641972311,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foodborne Pathogens and Disease"],"published-print":{"date-parts":[[2014,9]]},"abstract":"\n Stilbenoids have a broad range of beneficial health effects. On the other hand, the emergence of antibiotic-resistant\n Staphylococcus aureus<\/jats:italic>\n presents a worldwide problem that requires new antibiotics or nonantibiotic strategies.\n S. aureus<\/jats:italic>\n produces \u03b1-hemolysin (a pore-forming cytotoxin) that has been implicated in the pathogenesis of sepsis and pneumonia. Furthermore, the biofilms formed by\n S. aureus<\/jats:italic>\n constitute a mechanism of antimicrobial resistance. In this study, we investigated the hemolytic and antibiofilm activities of 10 stilbene-related compounds against\n S. aureus<\/jats:italic>\n .\n trans<\/jats:italic>\n -Stilbene and resveratrol at 10\u2009\u03bcg\/mL were found to markedly inhibit human blood hemolysis by\n S. aureus<\/jats:italic>\n , and\n trans<\/jats:italic>\n -stilbene also inhibited\n S. aureus<\/jats:italic>\n biofilm formation without affecting its bacterial growth. Furthermore,\n trans<\/jats:italic>\n -stilbene and resveratrol attenuated\n S. aureus<\/jats:italic>\n virulence\n in vivo<\/jats:italic>\n in the nematode\n Caenorhabditis elegans<\/jats:italic>\n , which is normally killed by\n S. aureus<\/jats:italic>\n . Transcriptional analysis showed that\n trans<\/jats:italic>\n -stilbene repressed the \u03b1-hemolysin\n hla<\/jats:italic>\n gene and the intercellular adhesion locus (\n icaA<\/jats:italic>\n and\n icaD<\/jats:italic>\n ) in\n S. aureus<\/jats:italic>\n , and this finding was in line with observed reductions in virulence and biofilm formation. In addition, vitisin B, a stilbenoid tetramer, at 1\u2009\u03bcg\/mL was observed to significantly inhibit human blood hemolysis by\n S. aureus<\/jats:italic>\n .\n <\/jats:p>","DOI":"10.1089\/fpd.2014.1758","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T15:25:39Z","timestamp":1404919539000},"page":"710-717","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":62,"title":["Stilbenes Reduce\n Staphylococcus aureus<\/i>\n Hemolysis, Biofilm Formation, and Virulence"],"prefix":"10.1177","volume":"11","author":[{"given":"Kayeon","family":"Lee","sequence":"first","affiliation":[{"name":"Yeungnam University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Yeungnam University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi Yong","family":"Ryu","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Chemical Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo Hwan","family":"Cho","sequence":"additional","affiliation":[{"name":"Yeungnam University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintae","family":"Lee","sequence":"additional","affiliation":[{"name":"Yeungnam 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