{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:30:28Z","timestamp":1777642228347,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foodborne Pathogens and Disease"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    We assessed the susceptibility of 182\n                    <jats:italic toggle=\"yes\">Campylobacter jejuni<\/jats:italic>\n                    isolates from patients with diarrhea to eight antibiotics and analyzed the molecular mechanisms of ciprofloxacin resistance as well as the genetic characteristics based on multilocus sequence typing (MLST). The C257T mutation was found on the quinolone resistance-determining region (QRDR) of the\n                    <jats:italic toggle=\"yes\">gyr<\/jats:italic>\n                    A gene in all ciprofloxacin-resistant strains. Mutations on the QRDR of the\n                    <jats:italic toggle=\"yes\">gyr<\/jats:italic>\n                    B gene were silent. A total of 74 strains had 7 inverted repeat (IR) (a 16-bp IR on the intergenic region between\n                    <jats:italic toggle=\"yes\">cme<\/jats:italic>\n                    R and\n                    <jats:italic toggle=\"yes\">cme<\/jats:italic>\n                    ABC) mutation polymorphisms. Compared with strains without the IR mutations, strains with the IR mutations had higher resistance rates to ciprofloxacin (94.6% vs. 83.3%), nalidixic acid (94.6% vs. 83.3%), tetracycline (98.6% vs. 85.2%), doxycycline (91.9% vs. 71.3%), florfenicol (59.5% vs. 17.6%), chloramphenicol (25.7% vs. 4.6%), gentamicin (16.2% vs. 3.7%), and multidrug resistance than those without IR mutations (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). With C257T mutation alone, 89.9% strains with minimum inhibitory concentration (MIC) values focused on 16, 32, and 64\u2009\u03bcg\/mL, whereas strains with C257T mutation in combination with the IR mutations had a higher ciprofloxacin resistance level with 88.6% MIC values focused on 64, 128, and 512\u2009\u03bcg\/mL (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The strains in this study showed a high genetic variability based on MLST with 117 sequence types (STs), 37 of which were novel. CC-21 was the most common clonal complex (CC) followed by CC-353 and CC-45. No association was found between STs and ciprofloxacin resistance. In conclusion, the C257T mutation on\n                    <jats:italic toggle=\"yes\">gyr<\/jats:italic>\n                    A was the major mechanism for ciprofloxacin resistance, and the C257T mutation in combination with the IR mutations might result in more severe ciprofloxacin resistance to\n                    <jats:italic toggle=\"yes\">C. jejuni<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/fpd.2016.2223","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T16:26:15Z","timestamp":1499790375000},"page":"386-392","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["The Molecular Mechanisms of Ciprofloxacin Resistance in Clinical\n                    <i>Campylobacter jejuni<\/i>\n                    and Their Genotyping Characteristics in Beijing, China"],"prefix":"10.1177","volume":"14","author":[{"given":"Wanna","family":"Yang","sequence":"first","affiliation":[{"name":"Peking University First Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Disease Control and Prevention","place":["China"]},{"name":"Zhejiang University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Pang","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["China"]},{"name":"Zhejiang University","place":["China"]},{"name":"Peking University International Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengqin","family":"Hou","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["China"]},{"name":"Peking University International 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