{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:35:39Z","timestamp":1777642539989,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foodborne Pathogens and Disease"],"published-print":{"date-parts":[[2020,10]]},"abstract":"\n An\n Escherichia coli<\/jats:italic>\n strain isolated from the feces of swine at a pork slaughterhouse in Henan province China was found to possess two colistin-resistance genes,\n mcr-1<\/jats:italic>\n and\n mcr-3<\/jats:italic>\n , plus 16 additional resistance genes. Genes\n mcr-1.1<\/jats:italic>\n and\n mcr-3.1<\/jats:italic>\n were identified on IncHI2 and IncX1 type plasmids, respectively. Transconjugants (containing\n mcr-3<\/jats:italic>\n ,\n mcr-1<\/jats:italic>\n &\n mcr-3<\/jats:italic>\n ) were obtained that were 64- and 512-fold higher than the minimum inhibitory concentration of colistin on the recipient bacteria (\n E. coli<\/jats:italic>\n C600), respectively. The IncX1 plasmid containing\n mcr-3.1<\/jats:italic>\n displayed a very specific structure compared with previous\n mcr-3<\/jats:italic>\n . Variable and stable regions were similar across different plasmids, multiple insertion sequences and transposases.\n <\/jats:p>","DOI":"10.1089\/fpd.2019.2769","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T11:11:57Z","timestamp":1582197117000},"page":"597-601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Multidrug-Resistant\n Escherichia coli<\/i>\n Strain Isolated from Swine in China Harbors\n mcr-3.1<\/i>\n on a Plasmid of the IncX1 Type That Cotransfers with\n mcr-1.1<\/i>"],"prefix":"10.1177","volume":"17","author":[{"given":"Dewei","family":"Sun","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Jin","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajian","family":"Fan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengzhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Henan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin'an","family":"Jiao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China."},{"name":"Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02332-12"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142179"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.09.025"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2004.10.001"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01757-17"},{"key":"e_1_3_4_8_1","article-title":"Multilocus sequence typing and virulence profiles in uropathogenic Escherichia coli isolated from cats in the United States","volume":"10","author":"Liu X","year":"2015","unstructured":"Liu X, , Thungrat K, , Boothe DM. Multilocus sequence typing and virulence profiles in uropathogenic Escherichia coli isolated from cats in the United States. PLoS One, 2015; 10:e0143335.","journal-title":"PLoS One"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00424-7"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37125-1"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03900-14"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0288-0"},{"key":"e_1_3_4_13_1","article-title":"Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli","volume":"8","author":"Yin W","year":"2017","unstructured":"Yin W, , Li H, , Shen Y, , Liu Z, , Wang S, , Shen Z, , Zhang R, , Walsh TR, , Shen J, , Wang Y. Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. mBio, 2017; 8:e00543-17.","journal-title":"mBio"}],"container-title":["Foodborne Pathogens and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/fpd.2019.2769","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/fpd.2019.2769","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/fpd.2019.2769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:23:21Z","timestamp":1777443801000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/fpd.2019.2769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1089\/fpd.2019.2769"],"URL":"https:\/\/doi.org\/10.1089\/fpd.2019.2769","relation":{},"ISSN":["1535-3141","1556-7125"],"issn-type":[{"value":"1535-3141","type":"print"},{"value":"1556-7125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}