{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:10:42Z","timestamp":1787764242259,"version":"build-2784847793"},"reference-count":35,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foodborne Pathogens and Disease"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    is a global foodborne pathogen that causes human diseases ranging from mild gastroenteritis to severe systemic infections. Recently, antimicrobial blue light (aBL) showed effective bactericidal activity against a variety of bacteria (e.g.,\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    ) with varying efficiency. However, the antimicrobial mechanism of aBL has not been fully elucidated. Our previous report showed that the outer membrane (OM) is a key target of aBL. The major component of the OM, lipopolysaccharide (LPS), may play a role in aBL bactericidal effect. Therefore, the influence of LPS truncation on the sensitivity of\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium SL1344 to aBL was investigated for the first time. First, the\n                    <jats:italic toggle=\"yes\">rfaC<\/jats:italic>\n                    gene in the SL1344 strain likely involved in linking lipid A to the core region of LPS was inactivated and the influence on LPS structure was verified in the mutant strain SL1344\u0394\n                    <jats:italic toggle=\"yes\">rfaC<\/jats:italic>\n                    . SL1344\u0394\n                    <jats:italic toggle=\"yes\">rfaC<\/jats:italic>\n                    showed a significant increase in sensitivity to aBL, and the bactericidal efficiency exceeded 8 log CFU at an aBL dose of 383\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , while that of its parental SL1344 strain approached 4 log CFU. To discover the possible mechanism of higher sensitivity, the permeability of OM was determined. Compared to SL1344, SL1344\u0394\n                    <jats:italic toggle=\"yes\">rfaC<\/jats:italic>\n                    showed 2.7-fold higher permeability of the OM at 20\u2009J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , this may explain the higher vulnerability of the OM to aBL. Furthermore, the fatty acid profile was analyzed to reveal the detailed changes in the OM and inner membrane of the mutant. Results showed that the membrane lipids of SL1344\u0394\n                    <jats:italic toggle=\"yes\">rfaC<\/jats:italic>\n                    were markedly different to SL1344, indicating that change in fatty acid profile might mediate the enhancement of OM permeability and the increased sensitivity to aBL in SL1344\u0394\n                    <jats:italic toggle=\"yes\">rfaC<\/jats:italic>\n                    . Hence, we concluded that disruption of\n                    <jats:italic toggle=\"yes\">rfaC<\/jats:italic>\n                    in\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium led to the formation of truncated LPS and thus enhanced the permeability of the OM, which contributed to the increased sensitivity to aBL.\n                  <\/jats:p>","DOI":"10.1089\/fpd.2020.2888","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T12:05:43Z","timestamp":1629201943000},"page":"599-606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Enhanced Sensitivity of\n                    <i>Salmonella<\/i>\n                    to Antimicrobial Blue Light Caused by Inactivating\n                    <i>rfaC<\/i>\n                    Gene Involved in Lipopolysaccharide Biosynthesis"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4468-2889","authenticated-orcid":false,"given":"Xiaoqing","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China."},{"name":"International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghua","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Huazhong Agriculture University, Wuhan, 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