{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:01:46Z","timestamp":1784664106078,"version":"3.55.0"},"reference-count":54,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Foodborne Pathogens and Disease"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Listeria monocytogenes<\/jats:italic>\n                    poses significant public health and food safety risks due to its environmental resilience and pathogenicity. In this study, we utilized whole-genome sequencing to characterize 15\n                    <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                    strains isolated from Nantong, China (2020\u20132023), recovered from food and clinical samples. Antimicrobial susceptibility testing revealed that the Nantong isolates exhibited high resistance rates to ciprofloxacin (93.3%) and oxacillin (66.6%). Of particular concern, isolate NTLM03 exhibited the most extensive resistance profile, demonstrating resistance to six antimicrobials, including clindamycin, trimethoprim\/sulfamethoxazole, erythromycin, chloramphenicol, ciprofloxacin, and tetracycline. Seven distinct multilocus sequence types were identified, with ST9 being the most prevalent. Virulence analysis revealed premature stop codons in the\n                    <jats:italic toggle=\"yes\">inlA<\/jats:italic>\n                    gene of all ST9 isolates, a marker indicative of reduced virulence. In contrast, ST87 isolates carried the full-length\n                    <jats:italic toggle=\"yes\">inlA<\/jats:italic>\n                    gene and the complete\n                    <jats:italic toggle=\"yes\">Listeria<\/jats:italic>\n                    Pathogenicity Island-4 (\n                    <jats:italic toggle=\"yes\">LM9005581_70009<\/jats:italic>\n                    to\n                    <jats:italic toggle=\"yes\">LM9005581_70014<\/jats:italic>\n                    ), associated with high virulence. Core genome single nucleotide polymorphism (cgSNP) analysis demonstrated close relatedness (SNPs &lt;20) among isolates from the same batch of meat products (NTLM03, NTLM04, NTLM05), suggesting a potential common contamination source. Furthermore, we examined the genetic relatedness of Nantong isolates with domestic and international\n                    <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                    strains. Two characteristic\n                    <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                    plasmids were assembled: the multidrug-resistant (MDR) plasmid pNTLM03 and the cadmium-resistant plasmid pNTLM08. Surprisingly, pNTLM03 shared a highly similar MDR region with\n                    <jats:italic toggle=\"yes\">Listeria innocua<\/jats:italic>\n                    plasmids pLI42 and pLI203 from Chinese food sources. The transfer of antimicrobial resistance genes between\n                    <jats:italic toggle=\"yes\">Listeria<\/jats:italic>\n                    species and other genera through various genetic mechanisms may increase the potential for the evolution of resistant\n                    <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic>\n                    strains, thereby increasing the difficulty of clinical treatment.\n                  <\/jats:p>","DOI":"10.1089\/fpd.2025.0027","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T02:00:56Z","timestamp":1747101656000},"page":"418-426","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic Diversity, Antimicrobial Resistance, and Virulence Profiles of\n                    <i>Listeria monocytogenes<\/i>\n                    Isolates from Nantong, China (2020\u20132023)"],"prefix":"10.1177","volume":"23","author":[{"given":"Qin","family":"Shi","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Affiliated Hospital of Nantong University, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nantong Center for Disease Control and Prevention, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Affiliated Hospital of Nantong University, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nantong Center for Disease Control and Prevention, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nantong Center for Disease Control and Prevention, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nantong Center for Disease Control and Prevention, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2304-4717","authenticated-orcid":false,"given":"Ailong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nantong Center for Disease Control and Prevention, Nantong, 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