{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:39:24Z","timestamp":1777642764156,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Facial Plastic Surgery &amp; Aesthetic Medicine"],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Importance:<\/jats:title>\n                    <jats:p>A validated biomaterial would have several medical advantages in septorhinoplasties requiring a large-volume graft such as avoiding donor site morbidity, making ambulatory surgery possible, and reducing surgical costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the safety and efficacy of a ceramic to treat saddle and crooked noses. The main endpoint was the biocompatibility of the implant. The secondary endpoint was its functional and aesthetic efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants:<\/jats:title>\n                    <jats:p>The nasal septum (NASEPT) study is a pilot multicenter noncomparative prospective phase IIa clinical trial. The biomaterial tested was a biphasic calcium phosphate implant composed of 75% hydroxyapatite and 25% beta tri calcium phosphate. This versatile material can be used to replace septal skeleton when it is absent or nonusable. We included 25 patients with a multifractured osseous and cartilaginous framework after several traumas or surgeries. The implant placement technique was identical to an extracorporeal septoplasty through the external approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcomes and Measures:<\/jats:title>\n                    <jats:p>The primary endpoint was the occurrence of expected adverse and severe adverse events. The secondary endpoints were clinical functional and aesthetic results and histological microscopic modifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Any extrusion, infection, pain, and epistaxis were observed. All implants were placed in a sagittal, straight, and solid position without extralobular depression. Comparisons between pre- and postoperative symptoms showed that nasal comfort (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      ) and quality of life (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      ) were dramatically improved in all patients. The nasolabial angle (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.047) and the columellar projection (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.024) were improved after surgery. Histological data showed little submucosal inflammation at 6 months with well-differentiated epithelium. The mean follow-up was 23 months: three patients underwent revision surgery for functional or aesthetic details and four implants were removed (16%) owing to a foreign body reaction between 17 and 74 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>The NASEPT implant meets functional and aesthetic requirements in complex septorhinoplasties but its long-term biocompatibility needs to be improved. It could potentially avoid donor site morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/fpsam.2020.0184","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T10:19:41Z","timestamp":1595499581000},"page":"321-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Multicenter Pilot Study to Assess a Biphasic Calcium Phosphate Implant for Functional and Aesthetic Septorhinoplasty"],"prefix":"10.1177","volume":"23","author":[{"given":"Ludovic","family":"de Gabory","sequence":"first","affiliation":[{"name":"University Hospital of Bordeaux, Department of Otorhinolaryngology, Bordeaux, France."},{"name":"CHU Bordeaux, CIC 14-01 IT, Bordeaux, France."},{"name":"University of Bordeaux, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Boudard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Saint Augustin Hospital, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Bess\u00e8de","sequence":"additional","affiliation":[{"name":"CHU Limoges, Department of Otorhinolaryngology, Limoges, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Maillard","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Public Health Unit, Clinical Epidemiology Unit (USMR) &amp; CIC 14-01 EC, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Lacomme","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMS 3420 CNRS, US4 INSERM, Bordeaux Imaging Center, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Gontier","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMS 3420 CNRS, US4 INSERM, Bordeaux Imaging Center, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e8ne","family":"Durand","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, CIC 14-01 IT, Bordeaux, France."},{"name":"University of Bordeaux, Bordeaux, France."},{"name":"INSERM, Tissue Bioengineering, U1026, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Fricain","sequence":"additional","affiliation":[{"name":"INSERM, Tissue Bioengineering, U1026, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"B\u00e9nard","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Public Health Unit, Clinical Epidemiology Unit (USMR) &amp; CIC 14-01 EC, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Bordenave","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, CIC 14-01 IT, Bordeaux, France."},{"name":"University of Bordeaux, Bordeaux, France."},{"name":"INSERM, Tissue Bioengineering, U1026, Bordeaux, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2015.1081"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2014.914"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2014.1592"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2017.1363"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sju117"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.12.019"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2018.03.017"},{"key":"e_1_3_6_9_2","author":"Vila P","year":"2020","unstructured":"Vila P, , Jeanpierre LM, , Rizzi CJ, , Yaeger LH, , Chi JJ. 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