{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:32:00Z","timestamp":1790065920645,"version":"4.0.1"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Facial Plastic Surgery &amp; Aesthetic Medicine"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There are little data on the risk to a breastfeeding infant after facial botulinum toxin injections to the mother.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To detect the presence of botulinum toxin in breast milk from lactating subjects treated with facial botulinum toxin injections, as measured by enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>For this pilot study, lactating women were injected with standardized facial botulinum toxin type A (BTXA) (range 40\u201392\u2009U). Collected breast milk samples over 5 days were analyzed for the presence of botulinum toxin. Exclusion criteria included (1) lactating women still using their breast milk for their infant, (2) muscular disorders, (3) any medication that could interfere with neuromuscular function, (4) uncontrolled systemic disease, (5) pregnant, and (6) neuromodulator injection in the past 90 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Four lactating women were recruited. Eight samples had no BTXA detected, whereas 8 of the 16 total had detectible amounts, which were well below the reported lethal oral dose for an infant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although the exclusion of lactating women from receiving cosmetic botulinum toxin injections is out of an abundance of caution to the theoretical risk to the infant, this study helps support the notion that facial botulinum toxin injections do not warrant an interruption in breastfeeding. Further studies with larger sample sizes are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/fpsam.2023.0326","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T11:51:07Z","timestamp":1706874667000},"page":"523-526","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Analysis of Breast Milk Samples in Lactating Women After Undergoing Botulinum Toxin Injections for Facial Rejuvenation: A Pilot Study"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-2680","authenticated-orcid":false,"given":"Caroline","family":"Hudson","sequence":"first","affiliation":[{"name":"Hudson Facial Plastic Surgery, Chicago, Illinois, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker","family":"Wilson","sequence":"additional","affiliation":[{"name":"L&amp;P Aesthetics, Palo Alto, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lieberman","sequence":"additional","affiliation":[{"name":"L&amp;P Aesthetics, Palo Alto, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Mittelman","sequence":"additional","affiliation":[{"name":"Mittelman Plastic Surgery Center, Los Altos, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Parikh","sequence":"additional","affiliation":[{"name":"L&amp;P Aesthetics, Palo Alto, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"Van Horn NL Street M. Infantile Botulism. [Updated June 12 2023]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80754-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-057988"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.009"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12322"},{"key":"e_1_3_4_7_2","unstructured":"Centers for Disease Control and Prevention Proper Storage and Preparation of Breast Milk. Available from: https:\/\/www.cdc.gov\/breastfeeding\/recommendations\/handling_breastmilk.htm [Last accessed: September18 2023]."},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/am.13.6.1014-1022.1965"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034702"},{"key":"e_1_3_4_10_2","unstructured":"American Society of Plastic Surgeons. Plastic Surgery Statistics Report. 2020. https:\/\/www.plasticsurgery.org\/documents\/News\/Statistics\/2020\/plastic-surgery-statistics-full-report-2020.pdf\/ [Last accessed: September18 2023]."},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079904125003962"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197802092980620"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.60343"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11120686"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1059"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2022.0281"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.104661"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13663"}],"container-title":["Facial Plastic Surgery &amp; Aesthetic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/fpsam.2023.0326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/fpsam.2023.0326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/fpsam.2023.0326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:10:26Z","timestamp":1781557826000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/fpsam.2023.0326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1089\/fpsam.2023.0326"],"URL":"https:\/\/doi.org\/10.1089\/fpsam.2023.0326","relation":{},"ISSN":["2689-3614","2689-3622"],"issn-type":[{"value":"2689-3614","type":"print"},{"value":"2689-3622","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]}}}