{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:36:33Z","timestamp":1791315393204,"version":"4.3.1"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Facial Plastic Surgery &amp; Aesthetic Medicine"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Existing data on tranexamic acid (TXA) in rhinoplasty are mixed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Compare blood loss, edema, and bruising in patients undergoing septorhinoplasty with or without intravenous (IV) TXA, measured by estimated blood loss and photograph review of edema\/ecchymosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Randomized controlled trial (NCT05774717).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients undergoing open septorhinoplasty were eligible. Participants were randomized to receive 1 g IV TXA preoperatively or routine medications only. Intraoperative bleeding was measured using the Boezaart scale and sponge saturation. Patients rated periorbital edema\/ecchymosis at 1 week. Photos were reviewed by a facial plastic surgeon to grade edema\/ecchymosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 139 participants: 73 (53%) female, mean age of 42 \u00b1 15 years, and 13% revision procedures. Sixty-nine (50%) received TXA. Boezaart scores were 2.25 and 2.41 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.3), and sponge scores were 0.76 and 0.84 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.4) in the TXA and control groups, respectively. Postoperative edema\/ecchymosis were 1.15\/1.19 out of 4 in the TXA group, and 0.97\/1.05 in the control group. Surgeon-graded edema\/ecchymosis were 1.78\/1.76 (TXA) and 1.82\/1.86 (control). There was no difference in epistaxis, pain, or appearance satisfaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this study, there was no difference in bleeding, edema, ecchymosis, or postoperative experience associated with TXA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/fpsam.2024.0327","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T06:59:56Z","timestamp":1741157996000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Intravenous Tranexamic Acid in Rhinoplasty: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"28","author":[{"given":"Elizabeth S.","family":"Longino","sequence":"first","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole G.","family":"Desisto","sequence":"additional","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyi","family":"Adegboye","sequence":"additional","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Rebula","sequence":"additional","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naweed I.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-2172","authenticated-orcid":false,"given":"Priyesh N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Stephan","sequence":"additional","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9889-1363","authenticated-orcid":false,"given":"Shiayin F.","family":"Yang","sequence":"additional","affiliation":[{"name":"Otolaryngology &amp; Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.11.012"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta17100"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2023.10.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32641-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201171"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.08.062"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2023.101049"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-020-01387-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00128-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00163-1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800942"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16058"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.10.043"},{"issue":"5","key":"e_1_3_3_15_2","first-page":"363","article-title":"Impact of a tranexamic acid dosing practice guideline in reducing blood product administration in pediatric scoliosis surgery","volume":"92","author":"Jones KD","year":"2024","unstructured":"Jones KD, , Hatlevig C, , Thompson JA, et al. 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