{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:00:40Z","timestamp":1777654840994,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Games for Health Journal"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Acute and regular moderate-intensity endurance exercise (MIEE) is known to positively affect vascular function. The present study assessed if an exercise session in an innovative exergame called the ExerCube can induce similar vascular reactions as an MIEE session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty-eight healthy recreationally active participants (13 females and 15 males; aged 24.8\u2009\u00b1\u20093.9 years; with body mass index 23.2\u2009\u00b1\u20092.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) completed an exergaming session (EGS) in the ExerCube (25 minutes) and an MIEE session on a treadmill (35 minutes, 65%\u201370% of maximal heart rate [HR]) in a randomized order. Both before and throughout the 45 minutes after the training sessions, pulse wave velocity (PWV), total peripheral resistance (TPR), stroke volume (SV), and HR were recorded. The study was approved by the Research Ethics Board of the Martin-Luther-Universit\u00e4t Halle-Wittenberg (Medical Faculty of the Martin-Luther-Universit\u00e4t 2019-177).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were different hemodynamic responses to both types of exercises. PWV was significantly decreased 45 minutes after the EGS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant changes were detected after MIEE (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.109). TPR was significantly lower after both exercise sessions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Only the EGS resulted in a significant decrease in SV 15 minutes after exercise (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The HR was significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05) higher after both exercise sessions. After the EGS, the increase in HR was still significantly higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.011) 45 minutes after the session. The interaction effects revealed significant differences in PWV (15 minutes,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.035; 30 minutes,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.004; and 45 minutes,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001), favoring the EGS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The EGS seems to induce a relevant exercise stimulus that can modulate vascular function. Therefore, this exergame may present an effective tool for prevention of cardiovascular diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/g4h.2021.0196","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T16:05:48Z","timestamp":1641398748000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute Effects of Heart Rate-Controlled Exergaming on Vascular Function in Young Adults"],"prefix":"10.1177","volume":"11","author":[{"given":"Eva","family":"Kircher","sequence":"first","affiliation":[{"name":"Charit\u00e9 University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6875-9625","authenticated-orcid":false,"given":"Sascha","family":"Ketelhut","sequence":"additional","affiliation":[{"name":"Martin Luther University Halle-Wittenberg, Institute of Sport Science, Halle (Saale), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Ketelhut","sequence":"additional","affiliation":[{"name":"MSB Medical School Berlin, Faculty of Natural Science, Berlin Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2800-9720","authenticated-orcid":false,"given":"Lisa","family":"R\u00f6glin","sequence":"additional","affiliation":[{"name":"Martin Luther University Halle-Wittenberg, Institute of Sport Science, Halle (Saale), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-1120","authenticated-orcid":false,"given":"Anna Lisa","family":"Martin-Niedecken","sequence":"additional","affiliation":[{"name":"Zurich University of the Arts, Institute for Design Research, Department of Design, Z\u00fcrich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuno","family":"Hottenrott","sequence":"additional","affiliation":[{"name":"Martin Luther University Halle-Wittenberg, Institute of Sport Science, Halle (Saale), Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard G.","family":"Ketelhut","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany."},{"name":"Medical Center Berlin (MCB), Cardiology and Sports Medicine, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312669"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(12)61031-9","article-title":"Lancet Physical Activity Series Working Group. 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