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Here, we applied the 10x Genomics Visium Spatial Proteogenomics (Visium-SPG) platform, which couples spatial gene expression with immunofluorescence (IF) protein co-detection, to evaluate its ability to quantify changes in spatial gene expression with respect to amyloid-beta (A\u03b2) and hyperphosphorylated tau (pTau) pathology in post-mortem human brain tissue from individuals with Alzheimer's disease (AD). We identified transcriptomic signatures associated with proximity to A\u03b2 in the human inferior temporal cortex during late-stage AD, which we further investigated at cellular resolution with combined IF and single-molecule fluorescent\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization (smFISH). The study provides a data analysis workflow for Visium-SPG, and the data represent a proof-of-principle for the power of multi-omic profiling in identifying changes in molecular dynamics that are spatially associated with pathology in the human brain. We provide the scientific community with web-based, interactive resources to access the datasets of the spatially resolved AD-related transcriptomes.\n                  <\/jats:p>","DOI":"10.1089\/genbio.2023.0019","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:56:22Z","timestamp":1697536582000},"page":"399-417","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Influence of Alzheimer's Disease Related Neuropathology on Local Microenvironment Gene Expression in the Human Inferior Temporal Cortex"],"prefix":"10.1177","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5328-0956","authenticated-orcid":false,"given":"Sang Ho","family":"Kwon","sequence":"first","affiliation":[{"name":"The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins School of Medicine, Baltimore, Maryland, USA."},{"name":"Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA."},{"name":"The Solomon H. 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