{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:26:47Z","timestamp":1777660007324,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Testing"],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:p>\n                    Mutations in the leucine-rich repeat kinase 2 (\n                    <jats:italic toggle=\"yes\">LRRK2<\/jats:italic>\n                    ) gene represent the most common known genetic cause of inherited and idiopathic Parkinson's disease (PD) in different populations. The predicted multifunctionality of\n                    <jats:italic toggle=\"yes\">LRRK2<\/jats:italic>\n                    product and the pleomorphic pathology associated with\n                    <jats:italic toggle=\"yes\">LRRK2<\/jats:italic>\n                    mutations place this gene as a potential candidate for other neurodegenerative disorders, mainly Alzheimer's disease (AD). We report a Brazilian male expressing both late-onset AD and slowly progressive parkinsonism signs, and who presented the most frequent\n                    <jats:italic toggle=\"yes\">LRRK2<\/jats:italic>\n                    mutation (p.G2019S). Although the co-occurrence of PD and AD would be expected occasionally, the shared mechanisms between the two complex disorders are still unclear and are discussed herein. In light of recent findings about the wide role of\n                    <jats:italic toggle=\"yes\">LRRK2<\/jats:italic>\n                    under normal and pathological conditions, it is tempting to speculate that\n                    <jats:italic toggle=\"yes\">LRRK2<\/jats:italic>\n                    mutations might play an upstream influence on the etiology of not just PD but also several \u03b1-synuclein and tau pathologies, including AD.\n                  <\/jats:p>","DOI":"10.1089\/gte.2008.0042","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T09:06:08Z","timestamp":1229331968000},"page":"471-473","source":"Crossref","is-referenced-by-count":16,"title":["Co-occurrence of Sporadic Parkinsonism and Late-Onset Alzheimer's Disease in a Brazilian Male with the\n                    <i>LRRK2<\/i>\n                    p.G2019S Mutation"],"prefix":"10.1177","volume":"12","author":[{"given":"C\u00edntia B.","family":"Santos-Rebou\u00e7as","sequence":"first","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia B.","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Jos\u00e9 R.","family":"Baldi","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma A.","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana C.","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa P.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela S.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete B.","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerson","family":"Laks","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia M.G.","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,12,15]]},"container-title":["Genetic Testing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gte.2008.0042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gte.2008.0042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:21:16Z","timestamp":1777447276000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/gte.2008.0042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,12,1]]}},"alternative-id":["10.1089\/gte.2008.0042"],"URL":"https:\/\/doi.org\/10.1089\/gte.2008.0042","relation":{},"ISSN":["1090-6576","1557-7473"],"issn-type":[{"value":"1090-6576","type":"print"},{"value":"1557-7473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,1]]}}}