{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:27:26Z","timestamp":1777660046213,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"\n Dopamine receptor D2 (\n DRD2<\/jats:italic>\n ) is expressed in the central nervous system and has a high affinity for many antipsychotic drugs. Besides several epidemiological investigations on association of\n DRD2<\/jats:italic>\n locus polymorphism(s) with neuropsychiatric problems and addictive behavior, a few polymorphisms in this locus have also been used to understand genomic diversity and population migratory histories globally. The present study attempts to understand the genomic diversity\/affinity among four endogamous groups of Andhra Pradesh (India) against the backdrop of diversity studies from other parts of India and the rest of the world, with special reference to\n DRD2<\/jats:italic>\n locus. The four population groups from Adilabad District of Andhra Pradesh, namely, Brahmin (\n n<\/jats:italic>\n \u2009=\u200950), Nayakpod (\n n<\/jats:italic>\n \u2009=\u200949), Thoti (\n n<\/jats:italic>\n \u2009=\u200952), and Kolam (\n n<\/jats:italic>\n \u2009=\u200953), were included in the study. The\n DRD2<\/jats:italic>\n markers typed for the present study are three biallelic restriction fragments, that is,\n Taq<\/jats:italic>\n I A (rs1800497),\n Taq<\/jats:italic>\n I B (rs1079597), and\n Taq<\/jats:italic>\n I D (rs1800498). Scoring of\n DRD2<\/jats:italic>\n haplotypes with respect to the three\n Taq<\/jats:italic>\n I sites shows that five out of eight possible haplotypes are shared by the four populations. Ancestral haplotype B2D2A1 is most frequent among Thotis (0.359). The results of the present study indicate a differential gene flow into South India followed by certain important demographic events resulting in diversified peopling of India.\n <\/jats:p>","DOI":"10.1089\/gtmb.2008.0082","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T08:02:08Z","timestamp":1235548928000},"page":"115-119","source":"Crossref","is-referenced-by-count":4,"title":["Haplotype Diversity and Linkage Disequilibrium at\n DRD2<\/i>\n Locus\u2014A Study on Four Population Groups of Andhra Pradesh, India"],"prefix":"10.1177","volume":"13","author":[{"given":"Kallur Nava","family":"Saraswathy","sequence":"first","affiliation":[{"name":"University of Delhi (North Campus)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupak","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"University of Delhi (North Campus)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti","family":"Shukla","sequence":"additional","affiliation":[{"name":"University of Delhi (North Campus)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"University of Delhi (North Campus)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohinder Pal","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"University of Delhi (North Campus)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Rao","sequence":"additional","affiliation":[{"name":"Kakatiya University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti","family":"Saksena","sequence":"additional","affiliation":[{"name":"University of Delhi (North Campus)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloke Kumar","family":"Kalla","sequence":"additional","affiliation":[{"name":"University of Delhi (North Campus)","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2,9]]},"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2008.0082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2008.0082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:21:22Z","timestamp":1777447282000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/gtmb.2008.0082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2,1]]}},"alternative-id":["10.1089\/gtmb.2008.0082"],"URL":"https:\/\/doi.org\/10.1089\/gtmb.2008.0082","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,1]]}}}