{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:21:50Z","timestamp":1777659710132,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"<jats:p>\n                    We investigated the hypothesis that coinheritance of the common A(TA)\n                    <jats:sub>n<\/jats:sub>\n                    TAA promoter mutation at the\n                    <jats:italic toggle=\"yes\">UGT1A1<\/jats:italic>\n                    locus associated with Gilbert syndrome is a risk factor for gallstone formation in a homogeneous adult population, by conducting a case-control study that included 198 adult patients with cholelithiasis and 152 healthy controls both of Greek origin. Three genotypes were found: 7\/7 (17.8% in controls and 23.3% in patients), 6\/7 (33.5% in controls and 46.5% in patients), and normal homozygous 6\/6 (48.7% in controls and 30.3% in patients). The Gilbert\n                    <jats:italic toggle=\"yes\">UGT1A1<\/jats:italic>\n                    genotypes 6\/7 and 7\/7 show significant association (odds ratio 2.225, 95% confidence interval 1.373-3.605,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001, and odds ratio 2.101, 95% confidence interval 1.171-3.770,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.013, respectively) with cholelithiasis risk. This association supports the theory that genetic factors are responsible for a fraction of symptomatic gallstone disease; however, further studies are required in different ethnic groups to fully elucidate the involvement of Gilbert syndrome in gallstone disease.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2008.0095","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T08:02:08Z","timestamp":1235548928000},"page":"143-146","source":"Crossref","is-referenced-by-count":19,"title":["Gilbert Syndrome as a Predisposing Factor for Cholelithiasis Risk in the Greek Adult Population"],"prefix":"10.1177","volume":"13","author":[{"given":"Aspasia","family":"Tsezou","sequence":"first","affiliation":[{"name":"University of Thessaly Larissa","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tzetis","sequence":"additional","affiliation":[{"name":"University of Athens","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Giannatou","sequence":"additional","affiliation":[{"name":"University of Athens","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ierotheos","family":"Spanos","sequence":"additional","affiliation":[{"name":"General Hospital of Rhodes","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleutheria","family":"Roma","sequence":"additional","affiliation":[{"name":"\u201cAghia Sofia\u201d Children's Hospital","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Fretzayas","sequence":"additional","affiliation":[{"name":"Atticon University Hospital","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Kanavakis","sequence":"additional","affiliation":[{"name":"University of Athens","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Kitsiou-Tzeli","sequence":"additional","affiliation":[{"name":"University of Athens","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2,9]]},"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2008.0095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2008.0095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:20:21Z","timestamp":1777447221000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/gtmb.2008.0095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2,1]]}},"alternative-id":["10.1089\/gtmb.2008.0095"],"URL":"https:\/\/doi.org\/10.1089\/gtmb.2008.0095","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,1]]}}}