{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:25:16Z","timestamp":1777659916015,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:p>\n                    Toll-like receptor 2 (TLR2) is a recognition receptor for the widest repertoire of pathogen-associated molecular patterns. Two polymorphisms of\n                    <jats:italic toggle=\"yes\">TLR2<\/jats:italic>\n                    could be linked to reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) activation and to increased risk of infection (supposed-2029C&gt;T and 2258G&gt;A). We investigated the supposed-2029C&gt;T and 2258G&gt;A\n                    <jats:italic toggle=\"yes\">TLR2<\/jats:italic>\n                    polymorphisms in 422 critically ill patients of European origin from southern Brazil (295 with sepsis and 127 without sepsis) and reviewed 33 studies on these polymorphisms, conducting a quality assessment with a score system. Among our patients we found only one heterozygote (1\/422) for the supposed-2029C&gt;T and none for the 2258G&gt;A (0\/422) single nucleotide polymorphism (SNP). We were unable to find a clinical application of supposed-2029T and 2258A allele analyses in our southern Brazilian population. Our review detected that current\n                    <jats:italic toggle=\"yes\">TLR2<\/jats:italic>\n                    SNP assays had very controversial and contradictory results derived from reports with a variety of investigation quality criteria. We suggest that, if analyzed alone, the supposed-2029C&gt;T and 2258G&gt;A\n                    <jats:italic toggle=\"yes\">TLR2<\/jats:italic>\n                    SNP are not good candidates for genetic markers in studies that search for direct or indirect clinical applications between genotype and phenotype. Future efforts to improve the knowledge and to provide other simultaneous genetic markers might reveal a more effective\n                    <jats:italic toggle=\"yes\">TLR2<\/jats:italic>\n                    effect on the susceptibility to infectious diseases.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2009.0169","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T15:04:05Z","timestamp":1277564645000},"page":"405-419","source":"Crossref","is-referenced-by-count":3,"title":["Very Low Frequencies of Toll-Like Receptor 2 Supposed-2029T and 2258A (RS5743708) Mutant Alleles in Southern Brazilian Critically Ill Patients: Would It Be a Lack of Worldwide-Accepted Clinical Applications of Toll-Like Receptor 2 Variants?"],"prefix":"10.1177","volume":"14","author":[{"given":"Helena Strelow","family":"Thurow","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cladinara Roberts","family":"Sarturi","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Roberto Vargas","family":"Fallavena","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis Jackson","family":"de Oliveira Paludo","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane Bentes","family":"Pican\u00e7o","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Rosa","family":"Fraga","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietra","family":"Graebin","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Carolino","family":"de Souza","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica de Bras\u00edlia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Suparregui","family":"Dias","sequence":"additional","affiliation":[{"name":"Unidade de Terapia Intensiva","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ot\u00e1vio","family":"de Tol\u00eado N\u00f3brega","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica de Bras\u00edlia","place":["Brazil"]},{"name":"Universidade de Bras\u00edlia","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarice Sampaio","family":"Alho","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,6,26]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199206000-00025"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1391"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02212.x"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-007-0081-4"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.11.3.625-626.2004"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0677-x"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01092.x"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.7.1153"},{"key":"e_1_3_3_11_1","unstructured":"BLAST. 2008. 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