{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:49:18Z","timestamp":1790182158152,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T00:00:00Z","timestamp":1287964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Introduction:<\/jats:italic>\n                    The Fc\u03b3RIIa receptor is responsible for the clearance of large immune complexes and recently has been proved to be a C-reactive protein (CRP) receptor as well. A polymorphism in the corresponding\n                    <jats:italic toggle=\"yes\">FCG2RA<\/jats:italic>\n                    gene resulting in an amino acid change (R131H) has been implicated, with conflicting results in the pathogenesis of various autoimmune or inflammatory disorders (e.g., atherosclerosis and coronary artery disease [CAD]).\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    We recently developed a real-time polymerase chain reaction and melting curve analysis method for the genotyping of the above polymorphism. We further looked at its validity with bioinformatics study and DNA sequencing. Then we genotyped 134 CAD patients and 45 angiographically normal controls and determined serum high-sensitivity CRP by nephelometry (Dade-Behring). Also, we used apparently healthy platelet donors (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009206) as a larger control group.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    Our method is accurate and devoid of problems with homologs and copy number variants. The need for reference materials is stressed. There were statistically significant differences (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) between the CAD patients and each of the two other control groups, with the percentage of RR genotype rising from 6.5% and 11% in the control groups to an average of 19% in all CAD patients (17%, 24%, and 18.5% in stable angina, unstable angina, and myocardial infarction, respectively). In a logistic regression model that included known risk factors for CAD including CRP, the RR genotype remained a significant predictor for CAD (odds ratio: 6.3 [1.1-36.3]). Also after linear regression analysis, CRP levels were reduced in the RR carriers (vs. HH\u2009+\u2009HR), controlling for age, sex, and disease (marginal\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.07).\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    With our accurate genotyping method, the RR genotype was correlated with atherothrombotic CAD events. The inverse correlation found between CRP levels and genotype supports the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    data of RR cells binding CRP stronger than HH.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2010.0108","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T14:17:21Z","timestamp":1288016241000},"page":"839-846","source":"Crossref","is-referenced-by-count":18,"title":["The Association Between a Common\n                    <i>FCGR2A<\/i>\n                    Polymorphism and C-Reactive Protein and Coronary Artery Disease Revisited"],"prefix":"10.1177","volume":"14","author":[{"given":"Christos","family":"Kroupis","sequence":"first","affiliation":[{"name":"Attikon University Hospital","place":["Greece"]},{"name":"Onassis Cardiac Center","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Theodorou","sequence":"additional","affiliation":[{"name":"Attikon University Hospital","place":["Greece"]},{"name":"Onassis Cardiac Center","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antigoni","family":"Chaidaroglou","sequence":"additional","affiliation":[{"name":"Onassis Cardiac Center","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dalamaga","sequence":"additional","affiliation":[{"name":"Attikon University Hospital","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Attikon University Hospital","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis V.","family":"Cokkinos","sequence":"additional","affiliation":[{"name":"Onassis Cardiac Center","place":["Greece"]},{"name":"Biomedical Research Foundation","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Degiannis","sequence":"additional","affiliation":[{"name":"Onassis Cardiac Center","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Manginas","sequence":"additional","affiliation":[{"name":"Onassis Cardiac Center","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,10,25]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.2.370"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614938"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.4.585"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.0463"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20997"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05383.x"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00179-X"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<7::AID-HUMU4>3.0.CO;2-N"},{"key":"e_1_3_1_10_1","first-page":"223","volume-title":"Heparin-Induced Thrombocytopenia","author":"Denomme GA","year":"2004","unstructured":"Denomme GA. 2004. 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