{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:27:02Z","timestamp":1777660022930,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:00:00Z","timestamp":1286841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    Studies investigating the association between p53 codon 72 polymorphism and gastric cancer risk report conflicting results. Our recent meta-analysis suggests that the p53 codon 72 polymorphism may be associated with gastric cancer among Asians.\n                    <jats:italic toggle=\"yes\">Aim:<\/jats:italic>\n                    The objective of this study was to investigate the association between p53 codon 72 polymorphism and gastric cancer risk in Chinese Han patients.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    We extracted the peripheral blood samples from 150 patients with gastric cancer and 150 control subjects. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to detect p53 codon 72 polymorphism in these patients.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    Patients with gastric cancer had a significantly lower frequency of Arg\/Arg (odds ratio [OR]\u2009=\u20090.48, 95% confidence interval [95% CI]\u2009=\u20090.28, 0.80;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.005) than control subjects. Patients with cardia gastric cancer had a significantly higher frequency of Pro\/Pro (OR\u2009=\u20092.26, 95% CI\u2009=\u20091.12, 4.55;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.02) than those with noncardia gastric cancer. Patients with advanced gastric cancer had a significantly higher frequency of Arg\/Arg (OR\u2009=\u20092.66, 95% CI\u2009=\u20091.06, 6.65;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03) than those with early gastric cancer. When stratified by the Lauren's classification, histological differentiation of gastric cancer, no statistically significant result was observed.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    This study suggests that the p53 codon 72 polymorphism may be associated with gastric cancer in Chinese Han patients, and that difference in genotype distribution may be associated with the location and stage of gastric cancer.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2010.0115","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T04:40:49Z","timestamp":1286944849000},"page":"829-833","source":"Crossref","is-referenced-by-count":16,"title":["p53 Codon 72 Polymorphism and Gastric Cancer Risk in a Chinese Han Population"],"prefix":"10.1177","volume":"14","author":[{"given":"Yong","family":"Zhou","sequence":"first","affiliation":[{"name":"Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Wu","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10,12]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.16.4961"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-006-0139-7"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/92.1.5"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2006.21.1.28"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.9.747"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10466"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00041-1"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.444"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10483"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1905840"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-083-3"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22057"},{"key":"e_1_3_3_15_1","first-page":"944","article-title":"Arginine and proline alleles of the p53 gene are associated with different locations of gastric cancer","volume":"52","author":"Lai KC","year":"2005","unstructured":"Lai KC, , Chen WC, , Tsai FJ et al. 2005. Arginine and proline alleles of the p53 gene are associated with different locations of gastric cancer. Hepatogastroenterology, 52:944-948.","journal-title":"Hepatogastroenterology"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.09.003"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81871-1"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/44432"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28000"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geg008"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21137"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1440"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410009456"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11548"},{"key":"e_1_3_3_26_1","first-page":"1115","article-title":"P53 codon 72 polymorphism and risk of gastric cancer in a Chinese population","volume":"11","author":"Shen H","year":"2004","unstructured":"Shen H, , Solari A, , Wang X et al. 2004. P53 codon 72 polymorphism and risk of gastric cancer in a Chinese population. Oncol Rep, 11:1115-1120.","journal-title":"Oncol Rep"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70356-8"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00867-9"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.07.004"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01212724"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0173"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.11.026"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i40.6536"},{"key":"e_1_3_3_34_1","first-page":"2151","article-title":"Age-associated increase of codon 72 Arginine p53 frequency in gastric cardia and non-cardia adenocarcinoma","volume":"9","author":"Zhang ZW","year":"2003","unstructured":"Zhang ZW, , Newcomb P, , Hollowood A et al. 2003. Age-associated increase of codon 72 Arginine p53 frequency in gastric cardia and non-cardia adenocarcinoma. 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