{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:33:30Z","timestamp":1777660410220,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:p>\n                    This study aimed to investigate the association between\n                    <jats:italic toggle=\"yes\">HLA DR\/DQ<\/jats:italic>\n                    and inflammatory bowel diseases (IBD) in Tunisian patients and to determine the relationship between\n                    <jats:italic toggle=\"yes\">HLA DR\/DQ<\/jats:italic>\n                    alleles with the clinical disease patterns. DNA typing of human leukocyte antigen (\n                    <jats:italic toggle=\"yes\">HLA<\/jats:italic>\n                    ) genes was performed in 70 ulcerative colitis (UC) patients, 40 Crohn's disease (CD) patients, and 123 healthy controls (HC) using a polymerase chain reaction sequence specific primer technique. Data were analyzed using Cochran-Mantel-Haenszel test and binary logistic regression. Compared with HC, IBD patients showed an increased frequency of the homozygous\n                    <jats:italic toggle=\"yes\">DRB1*07<\/jats:italic>\n                    genotype. This positive association was maintained when UC and CD were separately compared to HC. In UC patients,\n                    <jats:italic toggle=\"yes\">DQB1*03:02<\/jats:italic>\n                    was predictive of colonic extension whereas\n                    <jats:italic toggle=\"yes\">DRB1*13<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">DQB1*03:01<\/jats:italic>\n                    were associated limited disease localization (left-sided colitis and proctitis). The\n                    <jats:italic toggle=\"yes\">DRB1*15<\/jats:italic>\n                    allele increased in patients with extraintestinal manifestations. In CD, female patients showed an increased frequency of\n                    <jats:italic toggle=\"yes\">DRB1*13<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">DRB1*15<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">DQB1*06<\/jats:italic>\n                    alleles and\n                    <jats:italic toggle=\"yes\">DRB1*13-DQB1*06<\/jats:italic>\n                    haplotype, whereas a significant increase of\n                    <jats:italic toggle=\"yes\">DRB1*07<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">DQB1*02<\/jats:italic>\n                    alleles, and\n                    <jats:italic toggle=\"yes\">DRB1*07-DQB1*02<\/jats:italic>\n                    haplotype was noted in male patients. These results show a significant association of the homozygous\n                    <jats:italic toggle=\"yes\">HLA-DRB1*07<\/jats:italic>\n                    genotype with UC and CD and of several\n                    <jats:italic toggle=\"yes\">HLA DR\/DQ<\/jats:italic>\n                    alleles and haplotypes with the clinical phenotypes of these diseases in Tunisian patients. Because of limited statistical power, our study findings are subject to further investigation.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2011.0132","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T15:05:43Z","timestamp":1325862343000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Inflammatory Bowel Disease: Susceptibility and Disease Heterogeneity Revealed by Human Leukocyte Antigen Genotyping"],"prefix":"10.1177","volume":"16","author":[{"given":"Dorra","family":"Bouzid","sequence":"first","affiliation":[{"name":"Habib Bourguiba Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arwa","family":"Kammoun","sequence":"additional","affiliation":[{"name":"H\u00e9di Chaker Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Amouri","sequence":"additional","affiliation":[{"name":"H\u00e9di Chaker Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Mahfoudh","sequence":"additional","affiliation":[{"name":"H\u00e9di Chaker Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samy","family":"Haddouk","sequence":"additional","affiliation":[{"name":"Habib Bourguiba Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Tahri","sequence":"additional","affiliation":[{"name":"H\u00e9di Chaker Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafedh","family":"Makni","sequence":"additional","affiliation":[{"name":"H\u00e9di Chaker Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Masmoudi","sequence":"additional","affiliation":[{"name":"Habib Bourguiba Hospital","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.4121510.x"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036296"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.2.210"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1985.tb00411.x"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.69"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200311000-00003"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5089(21)00448-X"},{"key":"e_1_3_3_10_1","first-page":"239","article-title":"HLA-DR2 gene and Spanish patients with ulcerative colitis","volume":"90","author":"Fernandez Arquero M","year":"1998","unstructured":"Fernandez Arquero M, , Lopez Nava G, , Dela Concha EG et al. 1998. 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