{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:34:41Z","timestamp":1777660481266,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T00:00:00Z","timestamp":1333584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    Type 1 and type 2 diabetes, complicated with renal disease, have a significantly higher incidence in the Canary Islands than in mainland Spain and other European countries. Present-day Canarian inhabitants consist of a mixed population with North African indigenous and European colonizer ancestors who have rapidly evolved from a rural to an urban life style. The aim of this work was to assess the possible role of genetic and environmental factors on diabetes-related end-stage renal disease incidence in the Canary Islands.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    For both types of diabetes there is an ethnic susceptibility increased by diabetes family history. Whereas the Y-chromosome does not play a significant role, mitochondrial DNA (mtDNA) haplogroup differences point to a maternal origin for this ethnic predisposition, confirming susceptible and protective effects for haplogroups J and T, respectively. In addition, urban life style seems to be an additional risk factor for type 1 diabetes.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    The maternal ethnic predisposition to diabetes complicated with kidney disease detected in the Canary Islands signals mtDNA and X-chromosome markers as the best candidates to uncover the genetic predisposition to this disease.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2011.0207","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T16:18:27Z","timestamp":1333642707000},"page":"859-864","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetics, Environment, and Diabetes-Related End-Stage Renal Disease in the Canary Islands"],"prefix":"10.1177","volume":"16","author":[{"given":"Ana M.","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"University of La Laguna","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benito M.","family":"Maceira","sequence":"additional","affiliation":[{"name":"University of La Laguna","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estefan\u00eda","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente M.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"University of La Laguna","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso J.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Larruga","sequence":"additional","affiliation":[{"name":"University of La Laguna","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/290457a0"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.756809"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.344S"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01745.x"},{"key":"e_1_3_3_6_1","first-page":"1","article-title":"Study of mtDNA polymorphism in type 2 diabetes patients","volume":"16","author":"Buikin SV","year":"2008","unstructured":"Buikin SV, , Golubenko MV, , Puzyrev KV et al. 2008. 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