{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:33:55Z","timestamp":1777660435203,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T00:00:00Z","timestamp":1334534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Objectives:<\/jats:italic>\n                    The aim of this study was (1) to identify the profile of patients being referred for cytogenetic analysis in Morocco, (2) to determine the prevalence and type of chromosomal abnormalities in the different groups, (3) to compare the results with those of similar studies done in other countries.\n                    <jats:italic toggle=\"yes\">Material and Methods:<\/jats:italic>\n                    5572 patients ranging from newborns to 50 years of age were referred to the department of medical genetics, of the Moroccan National Institute of Health between 1993 and 2010, with a variety of clinical disorders such as mental retardation; multiple congenital malformations; clinical features of Down syndrome, Turner's syndrome, and Klinefelter syndrome; ambiguous sex; sterility; amenorrhea; recurrent miscarriage; and chromosome breakage syndromes.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    Of the 5572 cases studied, 4068 (73%) had a normal karyotype and 1504 (27%) had chromosomal abnormalities. Various types of chromosomal anomalies were found. The most common autosomal abnormalities were Down syndrome (1095 cases) and Turner's syndrome (122 cases) in abnormalities of sex chromosomes.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    This study compares the results of cytogenetic analysis of chromosomal abnormalities in the Moroccan population with other countries and research centers. This comparison will help Moroccan clinicians to determine the priority for requesting a cytogenetic analysis in individual cases.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2011.0265","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T12:39:36Z","timestamp":1334579976000},"page":"569-573","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Cytogenetic Analysis of 5572 Patients Referred for Suspected Chromosomal Abnormalities in Morocco"],"prefix":"10.1177","volume":"16","author":[{"given":"Nisrine","family":"Aboussair","sequence":"first","affiliation":[{"name":"National Institute of Health","place":["Morocco"]},{"name":"Cadi Ayyad University","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imane Cherkaoui","family":"Jaouad","sequence":"additional","affiliation":[{"name":"National Institute of Health","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souad Cherkaoui","family":"Dequaqui","sequence":"additional","affiliation":[{"name":"National Institute of Health","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziza","family":"Sbiti","sequence":"additional","affiliation":[{"name":"National Institute of Health","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatiha","family":"Elkerch","sequence":"additional","affiliation":[{"name":"National Institute of Health","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benbouchta","family":"Yahya","sequence":"additional","affiliation":[{"name":"National Institute of Health","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhafid","family":"Natiq","sequence":"additional","affiliation":[{"name":"National Institute of Health","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelaziz","family":"Sefiani","sequence":"additional","affiliation":[{"name":"National Institute of Health","place":["Morocco"]},{"name":"Mohamed V University","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,16]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"269","article-title":"A five year experience with autosomal abnormalities in Kuwait","volume":"19","author":"Al-Awadi SA","year":"1985","unstructured":"Al-Awadi SA et al. 1985. 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