{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:34:57Z","timestamp":1777660497474,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:00:00Z","timestamp":1342051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    Gout is caused by monosodium urate crystal-induced inflammation of the joints and periarticular tissues. Interleukin 10 (IL-10) is an important immunoregulatory cytokine, levels of which can be influenced by functional single-nucleotide polymorphisms in the promoter.\n                    <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    To investigate the association of \u22121082 G\/A and \u2212819 C\/T polymorphisms in the\n                    <jats:italic toggle=\"yes\">IL-10<\/jats:italic>\n                    promoter with gout susceptibility in the Chinese Han male population.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    A case-control study was performed in 302 patients and 284 controls. Genotyping of IL-10 \u22121082 G\/A and \u2212819 C\/T polymorphisms was performed by DNA sequencing techniques. An association analysis was analyzed by the\n                    <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    test.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    No significant differences were found in \u2212819T\/C and \u22121082\u2009A\/G genotypic and allelic frequencies between gout cases and controls (for \u2212819T\/C,\n                    <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =0.212, df=1,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.645 by genotype;\n                    <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =0.079, df=1,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.779 by allele; for \u22121082\u2009A\/G,\n                    <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =2.116, df=1,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.146 by genotype;\n                    <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =1.854, df=1,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.173 by allele).\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    IL-10 \u22121082 G\/A and \u2212819 C\/T polymorphisms may not be associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2011.0314","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T04:49:12Z","timestamp":1342154952000},"page":"879-883","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymorphisms \u22121082 G\/A and \u2212819 C\/T in the Interleukin-10 Gene Are Not Associated with Gout Susceptibility in the Chinese Han Male Population"],"prefix":"10.1177","volume":"16","author":[{"given":"Shiguo","family":"Liu","sequence":"first","affiliation":[{"name":"Qingdao University","place":["China"]},{"name":"Qingdao University","place":["China"]},{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Yin","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["China"]},{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Sun","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["China"]},{"name":"Qingdao University","place":["China"]},{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ren","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["China"]},{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Chu","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changgui","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao University","place":["China"]},{"name":"Qingdao University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,12]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20438"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402102"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken054"},{"key":"e_1_3_3_5_1","first-page":"1364","article-title":"High prevalence of gout and related risk factors in Taiwan's Aborigines","volume":"24","author":"Chang SJ","year":"1997","unstructured":"Chang SJ, , Ko YC, , Wang TN et al. 1997. 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