{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:57:13Z","timestamp":1789732633289,"version":"4.0.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T00:00:00Z","timestamp":1342569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Mutations at arginine 132 of isocitrate dehydrogenase 1\/2 (\n                      <jats:italic toggle=\"yes\">IDH1\/2<\/jats:italic>\n                      ) have recently been demonstrated to be recurrent gene alterations in acute myeloid leukemia (AML). Subsequently, this mutation was also found in a variety of other hematologic malignancies, including myelodysplastic syndromes, myeloproliferative diseases, and non-Hodgkin lymphoma. Only a few cases were so far identified in acute lymphoblastic leukemia (ALL). To study the\n                      <jats:italic toggle=\"yes\">IDH<\/jats:italic>\n                      status in ALL patients, we analyzed 54 adult and 34 pediatric ALL samples'\n                      <jats:italic toggle=\"yes\">IDH1\/2<\/jats:italic>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Three adult cases and no pediatric case with an isocitrate dehydrogenase 1 (\n                      <jats:italic toggle=\"yes\">IDH1<\/jats:italic>\n                      ) mutation were identified. No isocitrate dehydrogenase 2 (\n                      <jats:italic toggle=\"yes\">IDH2<\/jats:italic>\n                      ) mutation was identified in the total of 88 samples. The frequency of the\n                      <jats:italic toggle=\"yes\">IDH1<\/jats:italic>\n                      mutation in adult ALL was 5.5%. Among the three\n                      <jats:italic toggle=\"yes\">IDH1<\/jats:italic>\n                      -mutated patients, two had normal karyotype and expressed the myeloid lineage markers. All three patients with an\n                      <jats:italic toggle=\"yes\">IDH1<\/jats:italic>\n                      mutation relapsed or died within 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The results suggested that the\n                      <jats:italic toggle=\"yes\">IDH1<\/jats:italic>\n                      R132 mutation might be a recurrent gene alteration in ALL; patients carrying the mutation have a trend to aberrantly express myeloid antigen and the mutation may imply a dismal outcome.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2011.0323","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T05:27:49Z","timestamp":1342675669000},"page":"991-995","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Mutation Analysis of Isocitrate Dehydrogenase in Acute Lymphoblastic Leukemia"],"prefix":"10.1177","volume":"16","author":[{"given":"Yiqun","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejing","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchang","family":"Mi","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]},{"name":"Institute of Hematology and Blood Diseases Hospital","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,18]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-250878"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.133"},{"key":"e_1_3_3_4_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL)","volume":"9","author":"Bene MC","year":"1995","unstructured":"Bene MC, , Castoldi G, , Knapp W et al. 1995. Proposals for the immunological classification of acute leukemias. 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