{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:34:41Z","timestamp":1777660481556,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T00:00:00Z","timestamp":1337558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:p>\n                    An impeded blood flow through the femoral head is incriminated in the etiopathogenesis of osteonecrosis of the femoral head (ONFH). Vascular endothelial growth factor (\n                    <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                    ) is a strong angiogenic protein and also plays a role in the formation of cartilage and bone. The aim of this study was to evaluate the association of\n                    <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                    \u2212634G\/C polymorphism with ONFH in a Chinese population. A total of 220 unrelated patients with nontraumatic ONFH and 220 unrelated control subjects were consecutively enrolled in a hospital-based case-control study. A polymerase chain reaction-restriction fragment length polymorphism analysis was used to detect the\n                    <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                    \u2212634G\/C genotype. Patients with ONFH had a significantly higher frequency of the CC genotype (odds ratio=1.64, 95% confidence interval=1.03, 2.60;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.04) than controls. There were no significant associations between any genotypes and the cause of ONFH. Our results support the hypothesis that the\n                    <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                    \u2212634CC genotype is a risk factor of ONFH in the Chinese population. However, current results should be validated prospectively in larger cohorts.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2011.0384","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T16:37:41Z","timestamp":1337618261000},"page":"739-743","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Vascular Endothelial Growth Factor \u2212634G\/C Polymorphism Associated with Osteonecrosis of the Femoral Head in a Chinese Population"],"prefix":"10.1177","volume":"16","author":[{"given":"Bin","family":"Liu","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Harbin Medical University","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Harbin Medical University","place":["P.R. 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