{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:37:12Z","timestamp":1777660632528,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:00:00Z","timestamp":1379721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    To investigate the association between transforming growth factor-beta3 (TGF-\u03b23) genetic polymorphisms and nonsyndromic cleft lip and palate (NSCLP) risk.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    An extensive literature search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, and CBM databases from their inception through June 1st, 2013. Case-control studies addressing the correlation between\n                    <jats:italic toggle=\"yes\">TGF-\u03b23<\/jats:italic>\n                    gene polymorphisms and NSCLP risk. The genotype distribution of the controls should conform to Hardy-Weinberg equilibrium. The quality of the included studies was assessed independently by two authors based on the Newcastle-Ottawa scale. All analyses were calculated using the STATA 12.0 software.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    The association between\n                    <jats:italic toggle=\"yes\">TGF-\u03b23<\/jats:italic>\n                    gene polymorphisms and NSCLP risk was assessed. Eleven case-control studies were included with a total of 1601 NSCLP cases and 1463 healthy controls. Our meta-analysis results indicated that mutant variants of the\n                    <jats:italic toggle=\"yes\">TGF-\u03b23<\/jats:italic>\n                    gene may be associated with an increased risk of NSCLP, especially among Asian populations. Further subgroup analyses also revealed significant associations between mutant variants of the\n                    <jats:italic toggle=\"yes\">TGF-\u03b23<\/jats:italic>\n                    gene and an increased risk of NSCLP in the population-based and polymerase chain reaction-restriction fragment length polymorphism studies. Meta-regression analyses showed that ethnicity may be a major source of heterogeneity.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    Our meta-analysis suggests that\n                    <jats:italic toggle=\"yes\">TGF-\u03b23<\/jats:italic>\n                    gene polymorphisms may contribute to NSCLP susceptibility, especially among Asian populations.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2013.0334","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T09:07:49Z","timestamp":1379754469000},"page":"881-889","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Transforming Growth Factor-Beta3 Gene Polymorphisms and Nonsyndromic Cleft Lip and Palate Risk: A Meta-Analysis"],"prefix":"10.1177","volume":"17","author":[{"given":"Mingrui","family":"Tang","sequence":"first","affiliation":[{"name":"The First Hospital of China Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of China Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Han","sequence":"additional","affiliation":[{"name":"The First Hospital of China Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Guo","sequence":"additional","affiliation":[{"name":"The First Hospital of China Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of China Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,21]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2002_039_0332_tpoacp_2.0.co_2"},{"issue":"1","key":"e_1_3_2_3_1","first-page":"105","article-title":"Extracellular matrix and growth factors in the pathogenesis of some craniofacial malformations","volume":"51","author":"Carinci P","year":"2007","unstructured":"Carinci P, , Becchetti E, , Baroni T et al. 2007. 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