{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:20:25Z","timestamp":1783693225647,"version":"3.55.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Purpose:<\/jats:italic>\n                    The aim of this study is to examine whether or not myocilin (\n                    <jats:italic toggle=\"yes\">MYOC<\/jats:italic>\n                    ) genetic variations are associated with susceptibility to primary angle-closure glaucoma (PACG) in the Han Chinese population.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    Four single-nucleotide polymorphisms (SNPs)\u2014rs235913, rs183532, rs12076134, and rs235875\u2014in the\n                    <jats:italic toggle=\"yes\">MYOC<\/jats:italic>\n                    gene were genotyped in 212 adult patients with PACG and 255 age-, sex-, and ethnic-matched healthy controls by using a polymerase chain reaction-restriction fragment length polymorphism assay. Data were analyzed by chi-square analysis.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    The four SNPs in the\n                    <jats:italic toggle=\"yes\">MYOC<\/jats:italic>\n                    gene were in the Hardy-Weinberg equilibrium in all the subjects. The frequencies of A allele rs183532 were significantly different between the PACG patients and the controls (0.238 vs. 0.169,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.008; OR=1.541; 95% CI: 1.117-2.127). The frequencies of the AA genotype and A allele of rs235913 were increased in PACG patients compared with controls, but the difference was not significant (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.037,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.017, respectively). A comparison of the distributions of the genotypes and alleles of rs12076134 and rs235875 showed no statistically significant differences between the PACG patients and the controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &gt;0.05). Haplotype analysis indicated that the frequency of the AATG and AATA haplotypes was significantly higher for PACG patients than for control subjects (both\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001). However, the frequency of CGGA and CGTG haplotypes was lower for PACG patients than for control subjects (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001).\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    Our study suggests that rs183532 is associated with an increased risk of PACG in the Chinese Han population.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0130","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T16:36:14Z","timestamp":1412094974000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Haplotype Analysis of Association of the\n                    <i>MYOC<\/i>\n                    Gene with Primary Angle-Closure Glaucoma in a Han Chinese Population"],"prefix":"10.1177","volume":"19","author":[{"given":"Xin","family":"Jin","sequence":"first","affiliation":[{"name":"General Hospital of Chinese People's Liberation Army","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"General Hospital of Chinese People's Liberation Army","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Hui","family":"Qu","sequence":"additional","affiliation":[{"name":"No. 181 Hospital of Guilin","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Ke","family":"Hou","sequence":"additional","affiliation":[{"name":"General Hospital of Chinese People's Liberation Army","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"General Hospital of Chinese People's Liberation Army","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"General Hospital of Chinese People's Liberation Army","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0780"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.12.2091"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.06.043"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1163"},{"key":"e_1_3_3_6_1","first-page":"1420","article-title":"Matrix metalloproteinase-9 genetic variation and primary angle closure glaucoma in a Caucasian population","volume":"17","author":"Awadalla MS","year":"2011","unstructured":"Awadalla MS, , Burdon KP, , Kuot A, et al. 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