{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:42:16Z","timestamp":1777660936220,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    This study aims to determine the correlation of erythrocyte complement receptor 1 (\n                    <jats:italic toggle=\"yes\">ECR1<\/jats:italic>\n                    ) A3650G (His1208Arg, rs2274567) polymorphism with the pathogenesis and development of neonatal respiratory distress syndrome (NRDS).\n                    <jats:italic toggle=\"yes\">Materials and Methods:<\/jats:italic>\n                    This case-control study was conducted at the Huaihe Hospital of Henan University. Sixty-six infants who met the diagnostic criteria of NRDS were placed into the case group. There were 60 healthy infants without respiratory symptoms in the control group. Genetic analyses were conducted using peripheral blood-extracted genomic DNA. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was applied to detect SNP.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    No apparent differences in gender, weight, and gestational age were observed between NRDS and healthy infants (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &gt;0.05). However, the NRDS group had more premature infants than the control group (59.1% vs. 38.3%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.019). In the NRDS group, the premature infants had shorter gestational ages than the full-term infants, while the duration of mechanical ventilation and oxygen inhalation for premature infants was longer than those of full-term infants (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05). Genotype frequencies were in Hardy-Weinberg equilibrium in both the NRDS and control groups (both\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &gt;0.05). The results showed that the A carrier (AG\/GG) and the A allele of the\n                    <jats:italic toggle=\"yes\">ECR1<\/jats:italic>\n                    A3650G polymorphism were associated with risk for NRDS (both\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05). Furthermore, premature infants with NRDS had higher frequencies of the A carrier (AG\/GG) of\n                    <jats:italic toggle=\"yes\">ECR1<\/jats:italic>\n                    A3650G polymorphism than full-term infants (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.002).\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    Our findings provide evidence that the A carrier (AG\/GG) and the A allele of the\n                    <jats:italic toggle=\"yes\">ECR1<\/jats:italic>\n                    A3650G polymorphism may be correlated to the pathogenesis of NRDS and, hence, might be involved in the susceptibility to NRDS.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0192","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T15:08:49Z","timestamp":1418224129000},"page":"18-23","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation of\n                    <i>ECR1<\/i>\n                    A3650G Polymorphism with Neonatal Respiratory Distress Syndrome"],"prefix":"10.1177","volume":"19","author":[{"given":"Ying","family":"Dai","sequence":"first","affiliation":[{"name":"Henan University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"He","sequence":"additional","affiliation":[{"name":"Henan University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[{"name":"Henan University","place":["People's Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318298a6db"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12274"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.03.007"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.1800109.x"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.24"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.06.001"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182a6384f"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000272047"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328360bbe7"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr900831f"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.08.003"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.04.015"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.08.032"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3212"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23894"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.06.002"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.09.026"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01133.x"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.05.019"},{"key":"e_1_3_3_21_1","first-page":"423","article-title":"Relationship between the erythrocyte CR1 genomic density polymorphism and erythrocyte immune function in children with recurrent respiratory tract infections","volume":"22","author":"Li HL","year":"2006","unstructured":"Li HL, , Jin P, , Huang YK, et al. 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