{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:42:21Z","timestamp":1777660941070,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    Ankylosing spondylitis (AS) is a genetically determined disease. Runt-related transcription factor 3 (\n                    <jats:italic toggle=\"yes\">RUNX3<\/jats:italic>\n                    ), tumor necrosis factor family member-associated NF-\u03baB activator binding kinase 1 binding protein (\n                    <jats:italic toggle=\"yes\">TBKBP1<\/jats:italic>\n                    ), and peroxisome proliferator-activated receptor-gamma coactivator 1 beta (\n                    <jats:italic toggle=\"yes\">PPARGC1B<\/jats:italic>\n                    ) have recently been found to be associated with susceptibility to AS in patients of Western European descent. We hypothesize that these three genes may be related to clinical outcomes of Chinese Han AS patients.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    Blood samples were drawn from 396 HLA-B27-positive Chinese Han AS patients. Clinical indexes were scored for each patient, including the Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and modified Stoke Ankylosing Spondylitis Spine Score (mSASSS), which measure patients' function of daily life and severity of AS. Twelve tagSNPs were selected from these three genes and genotyped. We analyzed the clinical indexes in different genotyped patients to investigate the relationship between severity of AS and different genotypes.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    The rs11249215 SNP in\n                    <jats:italic toggle=\"yes\">RUNX3<\/jats:italic>\n                    and the rs7379457 and rs32579 SNPs in\n                    <jats:italic toggle=\"yes\">PPARGC1B<\/jats:italic>\n                    significantly affect the BASFI score in patients. The rs11249215, rs7551188, and rs1395621 SNPs in\n                    <jats:italic toggle=\"yes\">RUNX3<\/jats:italic>\n                    significantly affect the BASDAI scores. The two selected single nucleotide polymorphisms (SNPs) in\n                    <jats:italic toggle=\"yes\">TBKBP1<\/jats:italic>\n                    show no relationship with the clinical outcomes. None of the 12 SNPs is related to mSASSS. In conclusion,\n                    <jats:italic toggle=\"yes\">RUNX3<\/jats:italic>\n                    is related to both the severity of AS and the function of daily life.\n                    <jats:italic toggle=\"yes\">PPARGC1B<\/jats:italic>\n                    is related to the function of daily life.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0194","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T15:15:46Z","timestamp":1418224546000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Clinical Indexes and\n                    <i>RUNX3<\/i>\n                    ,\n                    <i>TBKBP1<\/i>\n                    ,\n                    <i>PPARGC1B<\/i>\n                    Polymorphisms in Chinese Han Patients with Ankylosing Spondylitis"],"prefix":"10.1177","volume":"19","author":[{"given":"Jun","family":"Liu","sequence":"first","affiliation":[{"name":"Tianjin Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Lian","sequence":"additional","affiliation":[{"name":"Tianjin Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Tianjin Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis L.","family":"Shi","sequence":"additional","affiliation":[{"name":"University of Chicago Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chai","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1203"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080871"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"issue":"3","key":"e_1_3_3_5_1","first-page":"iii9","article-title":"Staging of patients with ankylosing spondylitis: a preliminary proposal","volume":"61","author":"Braun J","year":"2002","unstructured":"Braun J, , van der Heijde D, , Dougados M, et al. (2002) Staging of patients with ankylosing spondylitis: a preliminary proposal. Ann Rheum Dis, 61 Suppl 3:iii9-iii23.","journal-title":"Ann Rheum Dis"},{"key":"e_1_3_3_6_1","first-page":"S43","article-title":"Genetics of ankylosing spondylitis","volume":"20","author":"Brown MA","year":"2002","unstructured":"Brown MA, , Wordsworth BP, , Reveille JD (2002) Genetics of ankylosing spondylitis. Clin Exp Rheumatol, 20:S43-S49.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_3_7_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of Bath ankylosing spondylitis disease functional index (BASFI)","volume":"21","author":"Calin A","year":"1994","unstructured":"Calin A, , Garrett S, , Whitelock H, et al. (1994) A new approach to defining functional ability in ankylosing spondylitis: the development of Bath ankylosing spondylitis disease functional index (BASFI). 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