{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:28:28Z","timestamp":1787160508223,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    Dysregulated expression of microRNAs is often found in gastric cancer, and it contributes to the pathogenesis of gastric cancer via regulation of the cell cycle, proliferation, apoptosis, migration, and invasion.\n                    <jats:italic toggle=\"yes\">Aim:<\/jats:italic>\n                    In this study, we aimed to investigate the role of miR-367 in the invasion and metastasis of gastric cancer.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    The correlation between the expression level of miR-367 and the clinicopathologic features of 37 patients with gastric cancer was analyzed by using real-time polymerase chain reaction (RT-PCR). In addition, we investigated the effect of miR-367 on the invasion and migration of the gastric cancer cell lines HS746T and SGC-7901 using transwell and scratch-wound assays, and the target gene of miR-367 was predicated and demonstrated by the bioinformatics method and luciferase reporter system, respectively.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    The results showed that the expression of miR-367 was significantly reduced in the gastric cancer tissues compared with the paraneoplastic tissues, and significantly correlated with the differentiation level, tumor-node-metastasis (TNM) stage, and metastasis of gastric cancer. Notably, the overexpression of miR-367 in gastric cancer cells inhibited the cellular migration and invasion. Furthermore, the luciferase reporter system demonstrated that Rab23 was a target gene of miR-367, and ectopic expression of Rab23 could reverse the invasion and migration inhibitory activity of miR-367.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    Our study shows that miR-367 is a key negative regulator of the invasion and metastasis of gastric cancer and establishes a strong rationale for developing miR-367 as a novel therapeutic agent against gastric cancer.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0210","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T17:03:25Z","timestamp":1418144605000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["The microRNA-367 Inhibits the Invasion and Metastasis of Gastric Cancer by Directly Repressing Rab23"],"prefix":"10.1177","volume":"19","author":[{"given":"Zhang","family":"Bin","sequence":"first","affiliation":[{"name":"The First Hospital Affiliated to the Xinxiang Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Dedong","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to the Xinxiang Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xiangjie","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to the Xinxiang Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Hongwei","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to the Xinxiang Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qinghui","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to the Xinxiang Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i35.3976"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00048712"},{"key":"e_1_3_3_5_1","first-page":"513","article-title":"Functional polymorphism in the MicroRNA-367 binding site as a prognostic factor for colonic cancer","volume":"33","author":"Chae YS","year":"2013","unstructured":"Chae YS, , Kim JG, , Kang BW, et al. (2013) Functional polymorphism in the MicroRNA-367 binding site as a prognostic factor for colonic cancer. 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Curr Pharm Des, 19:1273-1284.","journal-title":"Curr Pharm Des"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200611056"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.7.569"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.018"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.11.026"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.352"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.340"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103360108"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1714"}],"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/gtmb.2014.0210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2014.0210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2014.0210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:20:01Z","timestamp":1777447201000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/gtmb.2014.0210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,9]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2,1]]}},"alternative-id":["10.1089\/gtmb.2014.0210"],"URL":"https:\/\/doi.org\/10.1089\/gtmb.2014.0210","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,9]]}}}