{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:20:27Z","timestamp":1777659627021,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    Hereditary as well as acquired thrombophilia is associated with a higher incidence of severe obstetric complications such as preeclampsia, spontaneous pregnancy loss, placental abruption, and fetal growth retardation. The aim of our study was to examine the association of selected thrombophilic polymorphisms (factor V Leiden,\n                    <jats:italic toggle=\"yes\">MTHFR<\/jats:italic>\n                    C677T, and\n                    <jats:italic toggle=\"yes\">MTHFR<\/jats:italic>\n                    A1298C) with pregnancy complications in the Slovak majority population and the Roma (Gypsy) ethnic population. The study included 354 women; 120 patients and 105 controls from the Slovak majority population, 50 patients and 79 controls from the Slovak Roma population. Genotyping was performed by the real-time polymerase chain reaction method using TaqMan\n                    <jats:sup>\u00ae<\/jats:sup>\n                    MGB probes.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    A statistically significant higher frequency of factor V Leiden (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.001, odds ratio [OR]=5.9) and\n                    <jats:italic toggle=\"yes\">MTHFR<\/jats:italic>\n                    C677T polymorphism (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.011, OR=1.7) was observed in the Slovak majority patient group compared to the control group. The incidence of\n                    <jats:italic toggle=\"yes\">MTHFR<\/jats:italic>\n                    A1298C polymorphism between patients and controls did not differ significantly. None of the three polymorphisms studied was in association with pregnancy complications in the group of Roma women.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    Our study has confirmed the variable distribution of selected thrombophilic polymorphisms in different ethnic groups as well as their various effects on the clinical phenotype.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0232","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T15:08:07Z","timestamp":1419952087000},"page":"98-102","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Ethnic Differences in the Association of Thrombophilic Polymorphisms with Obstetric Complications in Slovak and Roma (Gypsy) Populations"],"prefix":"10.1177","volume":"19","author":[{"given":"Alexandra","family":"Bozikova","sequence":"first","affiliation":[{"name":"Presov University","place":["Slovakia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Gabrikova","sequence":"additional","affiliation":[{"name":"Presov University","place":["Slovakia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Pitonak","sequence":"additional","affiliation":[{"name":"J. 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