{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:42:04Z","timestamp":1778917324209,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Purpose:<\/jats:italic>\n                    To discuss the association between adiponectin (\n                    <jats:italic toggle=\"yes\">ADIPOQ<\/jats:italic>\n                    ) gene rs2241766 and rs1501299 polymorphisms and the risk of colorectal cancer, and to analyze the role of the interaction between these two loci and environmental factors in colorectal cancer pathogenesis.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    The case-control study was performed with a 1:1 match. A self-designed questionnaire was used to perform a face-to-face survey with 600 new primary colorectal cancer cases confirmed by histopathology as well as 600 cases of people receiving a physical examination at the same time. The general information, lifestyle, and diet habits, etc. were collected from two groups of study subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to identify\n                    <jats:italic toggle=\"yes\">ADIPOQ<\/jats:italic>\n                    rs2241766 and rs1501299 genotypes.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    After adjusting for factors such as colorectal cancer family history, body-mass index (BMI), daily sedentary time, weekly red meat intake frequency, as well regular tea drinking, conditional logistic regression analysis indicated that rs2241766 TG+GG carriers had a higher risk of colorectal cancer than TT carriers (OR=1.433, 95% CI: 1.014-1.985); rs1501299 GT+TT carriers had a lower risk of colorectal cancer than GG carriers (OR=0.723, 95% CI: 0.531-0.902). Generalized multifactor dimensionality reduction analysis showed that ADIPOQ rs2241766 and rs1501299 could have interaction with red meat intake (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.001).\n                    <jats:italic toggle=\"yes\">Conclusion: ADIPOQ<\/jats:italic>\n                    rs2241766 and rs1501299 single nucleotide polymorphisms (SNPs) could be associated with colorectal pathogenesis and could have interactions with red meat intake. Both factors impact colorectal cancer occurrence.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0238","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T15:02:40Z","timestamp":1418137360000},"page":"9-13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Association Between Adiponectin Polymorphisms and the Risk of Colorectal Cancer"],"prefix":"10.1177","volume":"19","author":[{"given":"Xin","family":"Guo","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuping","family":"You","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuenan","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlong","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Harbin Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.443"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000002840"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.259"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-94"},{"key":"e_1_3_3_6_1","first-page":"982769","article-title":"Serum adiponectin level and different kinds of cancer: a review of recent evidence","volume":"2012","author":"Izadi V","year":"2012","unstructured":"Izadi V, , Farabad E, , Azadbakht L (2012) Serum adiponectin level and different kinds of cancer: a review of recent evidence. 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